ArticleParasitology2019
A novel miRNA, miR-13664, targets CpCYP314A1 to regulate deltamethrin resistance in Culex pipiens pallens.
Article in Parasitology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Multi-omics insights into mosquito insecticide resistance for integrated vector management.PeerJ · 2026Review
- Comparative analysis of sequential and thermodynamic features of pre-miRNA in insects with various organisms and applying XGBoost for one-vs-rest binary classification.Scientific reports · 2025Article
- Metabolic resistance to pyrethroids with possible involvement of non-coding ribonucleic acids in Anopheles funestus, the major malaria vector in western Kenya.BMC genomics · 2025Article
- Review
- Non-Coding RNAs Potentially Involved in Pyrethroid Resistance of Anopheles funestus Population in Western Kenya.Research square · 2024Article
- Insights into the role of non-coding RNAs in the development of insecticide resistance in insects.Frontiers in genetics · 2024Review
- Enthralling genetic regulatory mechanisms meddling insecticide resistance development in insects: role of transcriptional and post-transcriptional events.Frontiers in molecular biosciences · 2023Review
- Exposure to Temperature and Insecticides Modulates the Expression of Small Noncoding RNA-Associated Transcripts in the Colorado Potato Beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae).Journal of insect science (Online) · 2022Article
- MiR-279-3p regulates deltamethrin resistance through CYP325BB1 in Culex pipiens pallens.Parasites & vectors · 2021Article
- Review
- Aedes aegypti miRNA-33 modulates permethrin induced toxicity by regulating VGSC transcripts.Scientific reports · 2021Article
- From Global to Local-New Insights into Features of Pyrethroid Detoxification in Vector Mosquitoes.Insects · 2021Review
- 20-Hydroxyecdysone (20E) signaling as a promising target for the chemical control of malaria vectors.Parasites & vectors · 2021Review
- Profiling of MicroRNAs in Midguts ofFrontiers in genetics · 2021Article
- Transcriptomic analysis of insecticide resistance in the lymphatic filariasis vector Culex quinquefasciatus.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Extensive insecticide use has led to the resistance of mosquitoes to these insecticides, posing a major barrier to mosquito control. Previous Solexa high-throughput sequencing of Culex pipiens pallens in the laboratory has revealed that the abundance of a novel microRNA (miRNA), miR-13664, was higher in a deltamethrin-sensitive (DS) strain than a deltamethrin-resistant (DR) strain. Real-time quantitative PCR revealed that the miR-13664 transcript level was lower in the DR strain than in the DS strain. MiR-13664 oversupply in the DR strain increased the susceptibility of these mosquitoes to deltamethrin, whereas inhibition of miR-13664 made the DS strain more resistant to deltamethrin. Results of bioinformatic analysis, quantitative reverse-transcriptase polymerase chain reaction, luciferase assay and miR mimic/inhibitor microinjection revealed CpCYP314A1 to be a target of miR-13664. In addition, downregulation of CpCYP314A1 expression in the DR strain reduced the resistance of mosquitoes to deltamethrin. Taken together, our results indicate that miR-13664 could regulate deltamethrin resistance by interacting with CpCYP314A1, providing new insights into mosquito resistance mechanisms.
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