Evidence map›Paper›PMID 29966501›Full record

ReviewToxicologic pathology2018

Immunohistochemistry in Investigative and Toxicologic Pathology.

Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert

Open access · bronzeAbstract readReview
In one paragraph

Review in Toxicologic pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 74 citations in OpenAlex.

  1. An overview of immunohistochemistry: Evidence and personal experience.The Journal of international medical research · 2026
    Review
  2. Article
  3. Review
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  5. Cross-reactivity and localization of Schistosoma mansoni antigen for immunodiagnosis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  6. Development of αβ and γδ T Cells in the Thymus and Methods of Analysis.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
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  18. Review
  19. An Optimized and Advanced Algorithm for the Quantification of Immunohistochemical Biomarkers in Keratinocytes.JID innovations : skin science from molecules to population health · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kyathanahalli S Janardhan1 Integrated Laboratory Systems Inc., Morrisville, North Carolina, USA.
Heather Jensen2 The Division of National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Natasha P Clayton2 The Division of National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Ronald A Herbert2 The Division of National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Integrated Laboratory Systems, Inc. · US

Funding

CMPB Pathology Support GroupZICES102505 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HERBERT, RONALD · 2014 to 2021
$67.7M
Intramural NIH HHS Z99 ES999999NULL Z99 ES999999
6 · The paper itself

Abstract

Immunohistochemistry (IHC) is a valuable tool in pathology. This review provides a brief description of the technical aspects of IHC and a detailed discussion on the variables that affect the results, interpretation, and reproducibility of IHC results. Lists of antibodies that have and have not worked in IHC on various mouse and rat tissues in our laboratory are provided as a guidance for selection of antibodies. An approach to IHC method optimization is presented. Finally, the critical information that should be included as a part of peer-reviewed manuscript is also discussed.

Indexed as

AnimalsAntibodiesClinical Laboratory TechniquesHumansImmunohistochemistryMicePathologyRatsReproducibility of ResultsTissue FixationToxicologyAntibodiesantibodiescontrolsfixationIHCmiceratreproducibility

Identifiers

PMID29966501
PMCPMC6033701
OpenAlexW2810458489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.