ArticlePLoS biology2018
Nonmonotonic recruitment of ventromedial prefrontal cortex during remote memory recall.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Benefits of spaced learning are predicted by the re-encoding of past experience in ventromedial prefrontal cortex.Cell reports · 2025Article
- Concurrent representations of reinstated and transformed memories and their modulation by reward.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Benefits of spaced learning are predicted by re-encoding of past experience in ventromedial prefrontal cortex.bioRxiv : the preprint server for biology · 2024Article
- Eye movements of recent and remote autobiographical memories: fewer and longer lasting fixations during the retrieval of childhood memories.Psychological research · 2021Article
- The relationship between hippocampal subfield volumes and autobiographical memory persistence.Hippocampus · 2021Article
- Characterising the hippocampal response to perception, construction and complexity.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Evidence supporting a time-limited hippocampal role in retrieving autobiographical memories.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- vmPFC Drives Hippocampal Processing during Autobiographical Memory Recall Regardless of Remoteness.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Effective connectivity during autobiographical memory search.Brain and behavior · 2020Article
- The Neural Dynamics of Novel Scene Imagery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Systems-level consolidation refers to the time-dependent reorganisation of memory traces in the neocortex, a process in which the ventromedial prefrontal cortex (vmPFC) has been implicated. Capturing the precise temporal evolution of this crucial process in humans has long proved elusive. Here, we used multivariate methods and a longitudinal functional magnetic resonance imaging (fMRI) design to detect, with high granularity, the extent to which autobiographical memories of different ages were represented in vmPFC and how this changed over time. We observed an unexpected time course of vmPFC recruitment during retrieval, rising and falling around an initial peak of 8-12 months, before reengaging for older 2- and 5-year-old memories. This pattern was replicated in 2 independent sets of memories. Moreover, it was further replicated in a follow-up study 8 months later with the same participants and memories, for which the individual memory representations had undergone their hypothesised strengthening or weakening over time. We conclude that the temporal engagement of vmPFC in memory retrieval seems to be nonmonotonic, revealing a complex relationship between systems-level consolidation and prefrontal cortex recruitment that is unaccounted for by current theories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.