Evidence map›Paper›PMID 29964345›Full record

ArticleHuman brain mapping2018

White matter microstructure in anorexia nervosa.

Andrea Phillipou, Sean P Carruthers, Maria A Di Biase, Andrew Zalesky, Larry A Abel, David J Castle, Caroline Gurvich, Susan L Rossell

Abstract read
In one paragraph

Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022
    Pooled it
  2. Pooled it
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  13. Neuroimaging and eating disorders.Current opinion in psychiatry · 2019
    Review
  14. The Neurobiology of Eating Disorders.Child and adolescent psychiatric clinics of North America · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Andrea PhillipouDepartment of Optometry & Vision Sciences, The University of Melbourne, Melbourne, Australia.ORCID 0000-0003-1009-6619
Sean P CarruthersCentre for Mental Health, Swinburne University of Technology, Melbourne, Australia.
Maria A Di BiasePsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard, Medical School, Massachusetts.
Andrew ZaleskyMelbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia.
Larry A AbelDepartment of Optometry & Vision Sciences, The University of Melbourne, Melbourne, Australia.
David J CastleDepartment of Psychiatry, The University of Melbourne, Melbourne, Australia.
Caroline GurvichMonash Alfred Psychiatry Research Centre, Monash University & The Alfred Hospital, Melbourne, Australia.
Susan L RossellDepartment of Mental Health, St Vincent's Hospital, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neurobiological underpinnings of anorexia nervosa (AN) are unclear. White matter deficits have been described in the illness, but findings are inconsistent between studies. The aim of this study was to investigate differences in white matter microstructure in AN using diffusion-weighted imaging (DWI). It was hypothesised that people with AN, relative to a healthy control (HC) group, would show decreased functional anisotropy (FA) and increased mean diffusivity (MD) in the fornix and superior longitudinal fasciculus, consistent with previous literature. Analyses were conducted on 23 females with AN and 26 age- and gender-matched HCs using tract-based spatial statistics (TBSS). The results revealed widespread FA decreases and MD increases in the AN group. Our hypothesis was largely supported, although FA differences were not specifically found in the fornix. The findings suggest extensive differences in white matter structure in AN, which may contribute to AN pathophysiology.

Indexed as

AdolescentAdultAnorexia NervosaDiffusion Magnetic Resonance ImagingFemaleHumansNeural PathwaysWhite MatterYoung Adultdiffusioneating disorderfractional anisotropymagnetic resonance imagingneurobiology

Identifiers

PMID29964345
PMCPMC6866266

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.