ArticleThe journal of pain2018
Nociceptive and Cognitive Changes in a Murine Model of Polytrauma.
Article in The journal of pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- The Impact of Sex on the Dysfunction of Endogenous Pain Control after Traumatic Brain Injury.Journal of neurotrauma · 2026Article
- Defining the Systemic Response to Flight After Polytrauma in a Murine Model.Military medicine · 2026Article
- OnabotulinumtoxinA inhibits dysregulation of descending pain modulation following mild traumatic brain injury in mice.The journal of headache and pain · 2025Article
- Exercise plasma improves traumatic brain injury outcomes in mice.Scientific reports · 2025Article
- Animal Models of Traumatic Brain Injury and Their Relevance in Clinical Settings.CNS neuroscience & therapeutics · 2025Review
- Pain-Related White-Matter Changes Following Mild Traumatic Brain Injury: A Longitudinal Diffusion Tensor Imaging Pilot Study.Diagnostics (Basel, Switzerland) · 2025Article
- Effects of immunosuppression after limb fracture in mice on nociceptive, cognitive, and anxiety-related outcomes.Pain reports · 2024Article
- Oxytocin Receptors on Calvarial Periosteal Innervation: Therapeutic Target for Post-Traumatic Headache?Pharmaceutics · 2024Article
- Mechanisms and treatments of chronic pain after traumatic brain injury.Neurochemistry international · 2023Review
- Effect of Voluntary Exercise on Endogenous Pain Control Systems and Post-traumatic Headache in Mice.The journal of pain · 2023Article
- Racial Differences in Head Pain and Other Pain-Related Outcomes After Mild Traumatic Brain Injury.Journal of neurotrauma · 2023Article
- Review
- Monoamine control of descending pain modulation after mild traumatic brain injury.Scientific reports · 2022Article
- Moderate traumatic brain injury triggers long-term risks for the development of peripheral pain sensitivity and depressive-like behavior in mice.Frontiers in neurology · 2022Article
- Cerebral blood flow network differences correlated with cognitive impairment in mild traumatic brain injury.Frontiers in neuroscience · 2022Article
- Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use Disorder.Journal of neurotrauma · 2022Review
- Acute and late administration of colony stimulating factor 1 attenuates chronic cognitive impairment following mild traumatic brain injury in mice.Brain, behavior, and immunity · 2021Article
- The role of deficient pain modulatory systems in the development of persistent post-traumatic headaches following mild traumatic brain injury: an exploratory longitudinal study.The journal of headache and pain · 2020Article
- Mild Traumatic Brain Injury Causes Nociceptive Sensitization through Spinal Chemokine Upregulation.Scientific reports · 2019Article
- An Exploratory Study of Endogenous Pain Modulatory Function in Patients Following Mild Traumatic Brain Injury.Pain medicine (Malden, Mass.) · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Polytrauma commonly involves concussion (mild traumatic brain injury [mTBI]) and peripheral trauma including limb fractures. Interactions between mTBI and peripheral injuries are poorly understood, both leading to chronic pain and neurobehavioral impairments. To elucidate these interactions, a murine polytrauma model was developed. mTBI alone resulted in similar increased mechanical allodynia in male and female mice. Female fracture and polytrauma groups displayed greater increases in hind paw tactile hypersensitivity for weeks after injury than did the respective male groups. Capsaicin-evoked spontaneous pain behaviors were greater in fracture and polytrauma female mice compared with male mice. The mTBI and polytrauma male mice displayed significant deficits in spatial working memory. All fracture, mTBI, or polytrauma groups had deficits in object recognition memory. Only male mTBI or polytrauma mice showed greater agitation and increased risk-taking behavior in open field testing as well as zero maze tests. Additionally, impaired diffuse noxious inhibitory control was observed in all mTBI and polytrauma mice. The model presented offers clinically relevant features useful for studying persistent pain as well as cognitive and other behavioral changes after TBI including polytrauma. A better understanding of nervous system dysfunction after TBI and polytrauma might help prevent or reduce persistent pain and disability in these patients. PERSPECTIVE: The polytrauma model presented has relevant features of chronic pain and neurobehavioral impairments useful for studying mechanisms involved in their development. This model may have special value in understanding altered descending pain modulation after TBI and polytrauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.