ArticleRespiratory physiology & neurobiology2019
Inputs to medullary respiratory neurons from a pontine subregion that controls breathing frequency.
Article in Respiratory physiology & neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- High proportions of respiratory and non-respiratory modulated pre-Bötzinger complex neurons receive monosynaptic inputs from the pontine respiratory group in rabbit.Respiratory physiology & neurobiology · 2026Article
- Mapping of afferent and efferent connections of phenylethanolamine N-methyltransferase-expressing neurons in the nucleus tractus solitarii.CNS neuroscience & therapeutics · 2024Article
- Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia.Nature communications · 2024Article
- Review
- Changes in pontine and preBötzinger/Bötzinger complex neuronal activity during remifentanil-induced respiratory depression in decerebrate dogs.Frontiers in physiology · 2023Article
- Interaction between the pulmonary stretch receptor and pontine control of expiratory duration.Respiratory physiology & neurobiology · 2021Article
- Dose-dependent Respiratory Depression by Remifentanil in the Rabbit Parabrachial Nucleus/Kölliker-Fuse Complex and Pre-Bötzinger Complex.Anesthesiology · 2021Article
- Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network.eLife · 2021Article
- Commentaries on Viewpoint: Nondyspnogenic acute hypoxemic respiratory failure in COVID-19 pneumonia.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Blood pressure drives multispectral tuning of inspiration via a linked-loop neural network.Journal of neurophysiology · 2020Article
- Multi-Level Regulation of Opioid-Induced Respiratory Depression.Physiology (Bethesda, Md.) · 2020Review
- Endogenous glutamatergic inputs to the Parabrachial Nucleus/Kölliker-Fuse Complex determine respiratory rate.Respiratory physiology & neurobiology · 2020Article
- Kölliker-Fuse/Parabrachial complex mu opioid receptors contribute to fentanyl-induced apnea and respiratory rate depression.Respiratory physiology & neurobiology · 2020Article
- Research Advances on Therapeutic Approaches to Congenital Central Hypoventilation Syndrome (CCHS).Frontiers in neuroscience · 2020Review
- Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P.eLife · 2019Article
- A spatially dynamic network underlies the generation of inspiratory behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The contribution of endogenous glutamatergic input in the ventral respiratory column to respiratory rhythm.Respiratory physiology & neurobiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Neurons in a subregion of the medial parabrachial (PB) complex control expiratory duration (TE) and the inspiratory on-switch. To better understanding the underlying mechanisms, this study aimed to determine the types of medullary neurons in the rhythmogenic preBötzinger/Bötzinger Complex (preBötC/BötC) and adjacent areas that receive synaptic inputs from the PB subregion and whether these inputs are excitatory or inhibitory in nature. Highly localized electrical stimuli in the PB subregion combined with multi-electrode recordings from respiratory neurons and phrenic nerve activities were used to generate stimulus-to-spike event histograms to detect correlations in decerebrate, vagotomized dogs during isocapnic hyperoxia. Short-time scale correlations were found in 237/442 or ∼54% of the ventral respiratory column (VRC) neurons. Inhibition of E-neurons was ∼2.5X greater than for I-neurons, while Pre-I and I-neurons were excited. These findings indicate that the control of TE and the inspiratory on-switch by the PB subregion are mediated by a marked inhibition of BötC E-neurons combined with an excitation of I-neurons, especially pre-I neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.