Evidence map›Paper›PMID 29964079›Full record

ReviewAdvanced drug delivery reviews2018

Current state of in vivo panning technologies: Designing specificity and affinity into the future of drug targeting.

Heather H Gustafson, Audrey Olshefsky, Meilyn Sylvestre, Drew L Sellers, Suzie H Pun

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. In vivo selection of synthetic nucleocapsids for tissue targeting.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Wanted: An endothelial cell targeting atlas for nanotherapeutic delivery in allograft organs.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Heather H GustafsonDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, United States.
Audrey OlshefskyDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, United States; Institute for Protein Design, University of Washington, Seattle, WA 98195, United States.
Meilyn SylvestreDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, United States.
Drew L SellersDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, United States; Institute for Stem Cell Biology and Regenerative Medicine, University of Washington, Seattle, WA 98195, United States.
Suzie H PunDepartment of Bioengineering, University of Washington, Seattle, WA 98195, United States; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, United States. Electronic address: spun@uw.edu.

Funding

EXPERIMENTAL PATHOLOGY OF CARDIOVASCULAR DISEASET32HL007312 · NHLBI · UNIVERSITY OF WASHINGTON · PI MAJESKY, MARK W., SCHWARTZ, STEPHEN MARK · 1985 to 2019
$11.8M
Synthetic Hemostats for Trauma TreatmentR01HL139007 · NHLBI · UNIVERSITY OF WASHINGTON · PI PUN, SUZIE H., WHITE, NATHAN J · 2017 to 2020
$2.3M
POTENTIATING BREAST CANCER THERAPIES BY TARGETING TUMOR-ASSOCIATED MACROPHAGER01CA177272 · NCI · UNIVERSITY OF WASHINGTON · PI PUN, SUZIE H. · 2014 to 2019
$2.0M
Astrocyte-specific ligand discovery by phage displayR21NS086500 · NINDS · UNIVERSITY OF WASHINGTON · PI HORNER, PHILIP J, PUN, SUZIE H. · 2015 to 2016
$479k
Targeting Ligands for autonomic uptake and drug delivery to the brain and spinal cordR21NS099654 · NINDS · UNIVERSITY OF WASHINGTON · PI SELLERS, DREW L · 2017 to 2018
$427k
NCI NIH HHS R01 CA177272NHLBI NIH HHS R01 HL139007NHLBI NIH HHS T32 HL007312NINDS NIH HHS R21 NS086500NINDS NIH HHS R21 NS099654
6 · The paper itself

Abstract

Targeting ligands are used in drug delivery to improve drug distribution to desired cells or tissues and to facilitate cellular entry. In vivo biopanning, whereby billions of potential ligand sequences are screened in biologically-relevant and complex conditions, is a powerful method for identification of novel target ligands. This tool has impacted drug delivery technologies and expanded our arsenal of therapeutics and diagnostics. Within this review we will discuss current in vivo panning technologies and ways that these technologies can be improved to advance next-generation drug delivery strategies.

Indexed as

Drug DesignAptamers, NucleotideDrug Delivery SystemsHumansLigandsSubstrate SpecificityAptamers, NucleotideLigandsAptamersBiopanningDrug deliveryIn vivoPeptidesViral capsids

Identifiers

PMID29964079
PMCPMC6512807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.