Evidence map›Paper›PMID 29963981›Full record

ArticleeLife2018

A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in

Renat N Khaliullin, Rebecca A Green, Linda Z Shi, J Sebastian Gomez-Cavazos, Michael W Berns, Arshad Desai, Karen Oegema

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
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  9. Cell-intrinsic mechanical regulation of plasma membrane accumulation at the cytokinetic furrow.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Article
  12. Enucleation of theLife science alliance · 2024
    Article
  13. Article
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  15. Article
  16. Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Non-muscle myosin 2 at a glance.Journal of cell science · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Renat N KhaliullinDepartment of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, San Diego, United States.
Rebecca A GreenDepartment of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, San Diego, United States.
Linda Z ShiDepartment of Bioengineering and Institute of Engineering in Medicine, University of California, San Diego, San Diego, United States.
J Sebastian Gomez-CavazosDepartment of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, San Diego, United States.
Michael W BernsDepartment of Bioengineering and Institute of Engineering in Medicine, University of California, San Diego, San Diego, United States.
Arshad DesaiDepartment of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, San Diego, United States.ORCID http://orcid.org/0000-0002-5410-1830
Karen OegemaDepartment of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, University of California, San Diego, San Diego, United States.ORCID http://orcid.org/0000-0001-8515-7514

Funding

Predoctoral and Postdoctoral Training in Cancer Cell BiologyT32CA067754 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEAN Y.J. WANG · 1995 to 2026
$6.5M
NCI NIH HHS T32 CA067754NIH HHS T32 CA067754
6 · The paper itself

Abstract

To ensure timely cytokinesis, the equatorial actomyosin contractile ring constricts at a relatively constant rate despite its progressively decreasing size. Thus, the per-unit-length constriction rate increases as ring perimeter decreases. To understand this acceleration, we monitored cortical surface and ring component dynamics during the first cytokinesis of the

Indexed as

Actin CytoskeletonAnimalsBiomechanical PhenomenaCaenorhabditis elegansCaenorhabditis elegans ProteinsContractile ProteinsCytokinesisEmbryo, NonmammalianFeedback, PhysiologicalGene ExpressionKineticsMechanotransduction, CellularMyosinsPressureRheologyanillinCaenorhabditis elegans ProteinsContractile ProteinsMyosinsanalytical mathematical modelanillinC. eleganscell biologycompression feedbackcomputational biologycontractile ringcortical surface compressionmyosin IIsystems biology

Identifiers

PMID29963981
PMCPMC6063732

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.