Evidence map›Paper›PMID 29963966›Full record

ArticleCell cycle (Georgetown, Tex.)2018

Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation.

Siti Nur Ain Roesley, John E La Marca, Andrew J Deans, Lisa Mckenzie, Randy Suryadinata, Peter Burke, Marta Portela, Hongyan Wang, Ora Bernard, Boris Sarcevic and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Siti Nur Ain Roesleya Cell Cycle and Cancer Unit , St Vincent's Medical Institute , Melbourne , Australia.
John E La Marcad Department of Biochemistry & Genetics , La Trobe Institute for Molecular Science, La Trobe University , Melbourne , Australia.ORCID 0000-0001-6442-9947
Andrew J Deansb Department of Medicine , University of Melbourne , Melbourne , Australia.ORCID 0000-0002-5271-4422
Lisa Mckenziec Cell Cycle & Development Laboratory , Peter MacCallum Cancer Centre , Melbourne , Australia.ORCID 0000-0002-1432-6496
Randy Suryadinataa Cell Cycle and Cancer Unit , St Vincent's Medical Institute , Melbourne , Australia.
Peter Burkec Cell Cycle & Development Laboratory , Peter MacCallum Cancer Centre , Melbourne , Australia.ORCID 0000-0003-3119-9879
Marta Portelac Cell Cycle & Development Laboratory , Peter MacCallum Cancer Centre , Melbourne , Australia.
Hongyan Wangf Neuroscience and Behavioral Disorders Program , Duke-National University of Singapore Graduate Medical School , Singapore.
Ora Bernardb Department of Medicine , University of Melbourne , Melbourne , Australia.
Boris Sarcevica Cell Cycle and Cancer Unit , St Vincent's Medical Institute , Melbourne , Australia.ORCID 0000-0002-8063-1050
Helena E Richardsond Department of Biochemistry & Genetics , La Trobe Institute for Molecular Science, La Trobe University , Melbourne , Australia.
The University of Melbourne · AULa Trobe University · AUNational University of Singapore · SGPeter MacCallum Cancer Centre · AU

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537
6 · The paper itself

Abstract

The SWI/SNF ATP-dependent chromatin-remodeling complex is an important evolutionarily conserved regulator of cell cycle progression. It associates with the Retinoblastoma (pRb)/HDAC/E2F/DP transcription complex to modulate cell cycle-dependent gene expression. The key catalytic component of the SWI/SNF complex in mammals is the ATPase subunit, Brahma (BRM) or BRG1. BRG1 was previously shown to be phosphorylated by the G ABBREVIATIONS: A-P: Anterior-Posterior; BAF: BRG1-associated factor; BMP: Bone Morphogenetic Protein; Brg1: Brahma-Related Gene 1; Brm: Brahma; BSA: Bovine Serum Albumin; CDK: Cyclin dependent kinase dpp: decapentaplegic; EdU: 5-Ethynyl 2'-DeoxyUridine; EGFR: Epidermal Growth Factor Receptor; en: engrailed; GFP: Green Fluorescent Protein; GST: Glutathione-S-Transferase; HDAC: Histone DeACetylase; JNK: c-Jun N-terminal Kinase; Mad: Mothers Against Dpp; MAPK: Mitogen Activated Protein Kinase; MB:: Myelin Basic Protein; nub: nubbin; pH3: phosphorylated Histone H3; PBS: Phosphate Buffered Saline; PBT: PBS Triton; PFA: ParaFormAldehydep; Rb: Retinoblastoma protein; PCV: Posterior Cross-Vein; Snr1: Snf5-Related 1; SWI/SNF: SWitch/Sucrose Non-Fermentable; TGFβ: Transforming Growth Factor β; TUNEL: TdT-mediated dUTP Nick End Labelling; Wg: Wingless; ZNC: Zone of Non-Proliferating Cells.

Indexed as

Cell CycleCell DifferentiationAllelesAnimalsCell Cycle ProteinsCell DeathCyclin-Dependent KinasesDrosophila melanogasterDrosophila ProteinsEpistasis, GeneticEpitheliumMutationPhosphorylationSignal TransductionS PhaseTrans-Activatorsbrm protein, DrosophilaCell Cycle ProteinsCyclin-Dependent KinasesDrosophila ProteinsTrans-ActivatorsBrmCDKCyclinDrosophilaSWI/SNF

Identifiers

PMID29963966
PMCPMC6133315
OpenAlexW2810147811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.