Evidence map›Paper›PMID 29963654›Full record

ArticleJournal of reward deficiency syndrome and addiction science2017

Hypothesizing Las Vegas and Sutherland Springs Mass Shooters Suffer from Reward Deficiency Syndrome: "Born Bad".

Thomas McLaughlin, Kenneth Blum, Bruce Steinberg, David Siwicki, Joseph Campione, Rajendra D Badgaiyan, Eric R Braverman, Edward J Modestino, Marjorie C Gondré-Lewis, David Baron and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of reward deficiency syndrome and addiction science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Thomas McLaughlinCenter for Psychiatric Medicine, North Andover, MA, USA.
Kenneth BlumDepartment of Psychiatry, University of Florida & McKnight Brain Institute, College of Florida, Gainesville, FL, USA.
Bruce SteinbergDepartment of Psychology, Curry College, Milton, MA, USA.
David SiwickiDepartment of Genetic Addiction Research, Geneus Health LLC, San Antonio, TX, USA.
Joseph CampioneCenter for Psychiatric Medicine, North Andover, MA, USA.
Rajendra D BadgaiyanDepartment of Psychiatry, Ichan School of Medicine, New York, NY, USA.
Eric R BravermanDepartment of Clinical Neurology, Path Foundation, New York, NY, USA.
Edward J ModestinoDepartment of Psychology, Curry College, Milton, MA, USA.
Marjorie C Gondré-LewisDepartments of Anatomy & Psychiatry, Howard University School of Medicine, Washington, DC, USA.
David BaronDepartment of Psychiatry & Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Deborah C MashDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
John GiordanoDivision of Nutrigenomics and therapy, John Giordano's Life Enhancement Aftercare Recovery Center, Ft. Lauderdale, FL, USA.
Panayotis K ThanosBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.
Buffalo Psychiatric Center · USCurry College · USNational Center for Post Traumatic Stress Disorder · USUniversity of Southern California · USChristus Health · USHoward University · USIstituto Giordano · ITUniversity of Miami · US

Funding

Excessive Alcohol Drinking Associated with GABA Alpha 2-Regulated TLR4 ExpressionR01AA021262 · NIAAA · HOWARD UNIVERSITY · PI AURELIAN, LAURE, GONDRE-LEWIS, MARJORIE C · 2013 to 2017
$2.3M
Dopamine Neurotransmission in Tourette SyndromeR01NS073884 · NINDS · UNIVERSITY OF MINNESOTA · PI BADGAIYAN, RAJENDRA D · 2012 to 2016
$2.2M
Skeletal Effects of MethylphenidateR01HD070888 · NICHD · STATE UNIVERSITY NEW YORK STONY BROOK · PI KOMATSU, DAVID E · 2013 to 2017
$1.6M
Detection of Dopamine Release During a Cognitive TaskR21MH073624 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BADGAIYAN, RAJENDRA D · 2005 to 2006
$368k
A Systematic Medical Approach to Reward Transformation (SMART) for Brain Health in Opioid Use DisorderR41MD012318 · NIMHD · VERSA INTEGRATED SOLUTIONS, INC. · PI BLUM, KENNETH, GONDRE-LEWIS, MARJORIE C · 2017 to 2017
$221k
Dopamine Neurotransmission in AddictionI01CX000479 · VA · VA WESTERN NEW YORK HEALTHCARE SYSTEM · PI BADGAIYAN, RAJENDRA D · 2013 to 2014
–
CSRD VA I01 CX000479NIAAA NIH HHS R01 AA021262NICHD NIH HHS R01 HD070888NIMHD NIH HHS R41 MD012318NIMH NIH HHS R21 MH073624NINDS NIH HHS R01 NS073884
6 · The paper itself

Abstract

The slaughters in Las Vegas and Sutherland Springs demand explanation, in the face of the ineffable. An understanding of the shooters' motives could restore our trust in our mutually cooperative existence. In this short communication we provide post-hoc rationale of both Stephen Paddock (Las Vegas mass shooting) and Devin Kelley (Southerland Springs mass shooting) and hypothesize that these shooters had genetically induced "Reward Deficiency Syndrome" (RDS) and a hypodopaminergia trait/state. In this particular case we are in pursuit of trying to obtain postmortem samples of mass shooters for subsequent epigenetic and neurogenetic analyses. It is our contention that early genetic identification of RDS and its pathological behaviors including hyper - sexuality, violence, a love for guns, even in children, could be a giant step forward in potentially saving lives.

Indexed as

ADHDGamblingGunsHypersexualityHypodopaminergiaMass shootingsReward Deficiency Syndrome (RDS)

Identifiers

PMID29963654
PMCPMC6022843
OpenAlexW2791955523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.