ArticleChronic stress (Thousand Oaks, Calif.)
Early Life Stress Associated With Increased Striatal
Article in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Effects of Lifelong Low Social Status on Inflammatory Markers in Adult Female Macaques.Biomolecules · 2026Article
- The Changes inJournal of molecular neuroscience : MN · 2021Article
- Early life stress and glutamate neurotransmission in major depressive disorder.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2020Article
- The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder.Annual review of pharmacology and toxicology · 2019Review
- The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?Pharmacology & therapeutics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
introductionUsing proton magnetic resonance spectroscopy imaging (
methodsEleven bonnet macaque males reared under VFD conditions and seven age-matched control subjects underwent
resultsVFD-reared monkeys exhibited significantly increased NAA/Cr concentrations in right VS/CN in comparison to normally-reared controls, controlling for multiple comparisons. In comparison to controls, VFD CSF CRF concentrations were directly associated with right VS/CN absolute NAA. Left hippocampal volume was inversely associated with left VS/CN
conclusionELS produced persistent increases in VS/CN NAA, which demonstrated specific patterns of association (or lack thereof) to ELS markers in comparison to non-VFD subjects. The data are broadly consistent with a stable nonhuman primate phenotype of anxiety and mood disorder vulnerability whereby
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.