Evidence map›Paper›PMID 29963643›Full record

ArticleAdvances in pediatric research2017

Molecular analysis of endotracheal tube biofilms and tracheal aspirates in the pediatric intensive care unit.

Matthew K Leroue, J Kirk Harris, Katherine M Burgess, Mark J Stevens, Joshua I Miller, Marci K Sontag, Yamila L Sierra, Brandie D Wagner, Peter M Mourani

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Matthew K LeroueDepartment of Pediatrics, Section of Emergency Medicine, University of Colorado School of Medicine, Anschutz Medical Center, and Children's Hospital Colorado, Aurora, CO, USA.
J Kirk HarrisDepartment of Pediatrics, Section of Pulmonary Medicine, University of Colorado School of Medicine, Anschutz Medical Center, and Children's Hospital Colorado, Aurora, CO, USA.
Katherine M BurgessDepartment of Epidemiology, Colorado School of Public Health, Anschutz Medical Center, Colorado School of Public Health, Aurora, CO, USA.
Mark J StevensDepartment of Pediatrics, Section of Pulmonary Medicine, University of Colorado School of Medicine, Anschutz Medical Center, and Children's Hospital Colorado, Aurora, CO, USA.
Joshua I MillerDepartment of Epidemiology, Colorado School of Public Health, Anschutz Medical Center, Colorado School of Public Health, Aurora, CO, USA.
Marci K SontagDepartment of Epidemiology, Colorado School of Public Health, Anschutz Medical Center, Colorado School of Public Health, Aurora, CO, USA.
Yamila L SierraChildren's Hospital Colorado, Aurora, CO, USA.
Brandie D WagnerDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
Peter M MouraniDepartment of Pediatrics, Section of Critical Care, University of Colorado School of Medicine, Anschutz Medical Center, and Children's Hospital Colorado, Aurora, CO, USA.
Children's Hospital Colorado · USColorado School of Public Health · USUniversity of Colorado Denver · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
The Microbiome, Virome and Host Responses Preceding Ventilator-Associated PneumonR01HL124103 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MOURANI, PETER M, SONTAG, MARCI K · 2014 to 2017
$2.7M
NCATS NIH HHS UL1 TR001082NHLBI NIH HHS R01 HL124103
6 · The paper itself

Abstract

backgroundVentilator-associated pneumonia (VAP) is a known complication of mechanically ventilated children in the pediatric intensive care unit (PICU). Endotracheal tube (ETT) biofilms are often implicated in the development of VAP by providing a conduit for pathogens to the lower respiratory tract.

methodsA prospective cohort study from April 2010-March 2011 of children 4 weeks to 18 years of age ventilated for greater than 72 hours to determine the microbiota of ETT biofilms and tracheal aspirates.

resultsThirty-three patients were included with a mean age of 6.1 years (SD ± 5.1 years) and average length of intubation of 8.8 days (SD ± 5.0 days). Bacterial communities from tracheal aspirates and the proximal and distal ends of ETTs were determined using 16S rRNA gene libraries. Statistical analysis utilized two-part statistics and the Wilcoxon signed rank sum test for comparison of bacterial communities. Sequencing revealed a predominance of oropharyngeal microbiota including

conclusionsETT biofilms and tracheal aspirates of intubated patients in the PICU primarily consisted of oropharyngeal microbiota, but had a significant representation of potentially pathogenic genera. While the majority of patients had similar microbiota when comparing their ETT biofilms and tracheal aspirates, a subset of patients showed a divergence between communities that requires further investigation.

Identifiers

PMID29963643
PMCPMC6023549
OpenAlexW2802611540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.