Evidence map›Paper›PMID 29963256›Full record

ArticleOncotarget2018

Nucleoporin 153 regulates estrogen-dependent nuclear translocation of endothelial nitric oxide synthase and estrogen receptor beta in prostate cancer.

Agnese Re, Claudia Colussi, Simona Nanni, Aurora Aiello, Lorenza Bacci, Claudio Grassi, Alfredo Pontecorvi, Antonella Farsetti

Abstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Subcellular Localization Guides eNOS Function.International journal of molecular sciences · 2024
    Review
  4. Advances in the understanding of nuclear pore complexes in human diseases.Journal of cancer research and clinical oncology · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Antibody Validation for Estrogen Receptor Beta.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Agnese ReNational Research Council (CNR), Institute of Cell Biology and Neurobiology (IBCN), Rome, Italy.
Claudia ColussiNational Research Council (CNR), Institute of Cell Biology and Neurobiology (IBCN), Rome, Italy.
Simona NanniUniversità Cattolica, Institute of Medical Pathology, Rome, Italy.
Aurora AielloNational Research Council (CNR), Institute of Cell Biology and Neurobiology (IBCN), Rome, Italy.
Lorenza BacciUniversità Cattolica, Institute of Medical Pathology, Rome, Italy.
Claudio GrassiUniversità Cattolica, Institute of Human Physiology, Rome, Italy.
Alfredo PontecorviUniversità Cattolica, Institute of Medical Pathology, Rome, Italy.
Antonella FarsettiNational Research Council (CNR), Institute of Cell Biology and Neurobiology (IBCN), Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleoporin 153 (Nup153), key regulator of nuclear import/export, has been recently associated to oncogenic properties in pancreatic and breast tumour cells modulating either cell motility and migration or gene expression by chromatin association. In the present work, we have characterized the role of Nup153 in a cellular model of prostate cancer (PCa). The analysis of several immortalized cell lines derived from freshly explants of prostate cancer specimens showed that Nup153 protein was higher and present in multimeric complexes with eNOS and ERβ as compared to normal/hyperplastic prostate epithelial cells. This phenomenon was enhanced in the presence of 17β-estradiol (E

Indexed as

eNOSEstrogen Receptor signalingmolecular biomarkersNucleoporin 153prostate cancer

Identifiers

PMID29963256
PMCPMC6021351

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.