Evidence map›Paper›PMID 29963246›Full record

ReviewOncotarget2018

Breast cancer recurrence after reconstruction: know thine enemy.

Elizabeth A Brett, Matthias M Aitzetmüller, Matthias A Sauter, Georg M Huemer, Hans-Günther Machens, Dominik Duscher

Abstract readReview
In one paragraph

Review in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Modified Keystone a Versatile Flap Reconstruction for Mastectomy Defects: Our Clinical Experience.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. [Breast reconstruction following cancer].Wiener klinische Wochenschrift · 2020
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth A BrettDepartment of Plastic and Hand Surgery, Technical University of Munich, Munich 81675, Germany.
Matthias M AitzetmüllerDepartment of Plastic and Hand Surgery, Technical University of Munich, Munich 81675, Germany.
Matthias A SauterDepartment of Plastic and Hand Surgery, Technical University of Munich, Munich 81675, Germany.
Georg M HuemerSection of Plastic and Reconstructive Surgery, Kepler University Hospital Linz, Linz 4020, Austria.
Hans-Günther MachensDepartment of Plastic and Hand Surgery, Technical University of Munich, Munich 81675, Germany.
Dominik DuscherDepartment of Plastic and Hand Surgery, Technical University of Munich, Munich 81675, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast reconstruction proceeding cancer treatment carries risk, regardless of the type of surgery. From fat grafting, to flap placement, to implants, there is no guarantee that reconstruction will not stimulate breast cancer recurrence. Research in this field is clearly divided into two parts: scientific interventional studies and clinical retrospective evidence. The reconstructive procedure offers hypoxia, a wound microenvironment, bacterial load, adipose derived stem cells; agents shown experimentally to cause increased cancer cell activity. This is compelling scientific evidence which serves to bring uncertainty and fear to the reconstructive procedure. In the absence of clinical evidence, this laboratory literature landscape is now informing surgical choices. Curiously, clinical studies have not shown a clear link between breast cancer recurrence and reconstructive surgery. Where does that leave us? This review aims to analyze the science and the surgery, thereby understanding the oncological fear which accompanies breast cancer reconstruction.

Indexed as

breast cancer recurrencebreast implantsfat graftingflapsreconstructive surgery

Identifiers

PMID29963246
PMCPMC6021250

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.