ArticleForensic toxicology2018
In vitro metabolism of synthetic cannabinoid AM1220 by human liver microsomes and
Article in Forensic toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- The role of microorganisms in the biotransformation of psychoactive substances and its forensic relevance: a critical interdisciplinary review.Forensic sciences research · 2023Review
- Phase I-metabolism studies of the synthetic cannabinoids PX-1 and PX-2 using three different in vitro models.Forensic toxicology · 2022Article
- Comparison between human liver microsomes and the fungus Cunninghamella elegans for biotransformation of the synthetic cannabinoid JWH-424 having a bromo-naphthyl moiety analysed by high-resolution mass spectrometry.Forensic toxicology · 2022Article
- A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market.Molecules (Basel, Switzerland) · 2021Article
- New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites.Frontiers in chemistry · 2019Review
- Determination of progesterone compounds in the crude methanol extract of benalu duku leaves.Veterinary world · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIdentifying intake of synthetic cannabinoids generally requires the metabolism data of the drugs so that appropriate metabolite markers can be targeted in urine testing. However, the continuous appearance of new cannabinoids during the last decade has made it difficult to keep up with all the compounds including {1-[(1-methylpiperidin-2-yl)methyl]-1
methodsMetabolic stability of AM1220 was analysed by liquid chromatography-tandem mass spectrometry in multiple reaction monitoring mode after 1 µM incubation in human liver microsomes for 30 min. Tentative structure elucidation of metabolites was performed on both human liver microsome and fungal incubation samples using liquid chromatography-high-resolution mass spectrometry.
resultsHalf-life of AM1220 was estimated to be 3.7 min, indicating a high clearance drug. Nine metabolites were detected after incubating human liver microsomes while seven were found after incubating
conclusionsThree most abundant metabolites in both human liver microsomes and
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