ArticleForensic toxicology2018
Pharmacological evaluation of new constituents of "Spice": synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds.
Article in Forensic toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 115 citations in OpenAlex.
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- Behavioral pharmacology of novel synthetic indazole, indole, and benzimidazole cannabinoids in rodents.Journal of cannabis research · 2026Article
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- Synthesis, Analytical Characterization, and Human CBBiomolecules · 2024Article
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- Structure-Activity Relationship and Functional Evaluation of Cannabinoid Type-1 Receptor.Biomolecules & therapeutics · 2024Article
- Pharmacological evaluation of new generation OXIZID synthetic cannabinoid receptor agonists.European journal of pharmacology · 2024Article
- Timeframe Analysis of Novel Synthetic Cannabinoids Effects: A Study on Behavioral Response and Endogenous Cannabinoids Disruption.International journal of molecular sciences · 2024Article
- GC-MS/MS analysis of synthetic cannabinoids 5F-MDMB-PICA and 5F-CUMYL-PICA in forensic cases.Bioanalysis · 2024Article
- A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.Molecules (Basel, Switzerland) · 2023Article
- Computational and Experimental Drug Repurposing of FDA-Approved Compounds Targeting the Cannabinoid Receptor CB1.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CBPharmacology research & perspectives · 2023Article
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- Phase I-metabolism studies of the synthetic cannabinoids PX-1 and PX-2 using three different in vitro models.Forensic toxicology · 2022Article
- Mepirapim, a Novel Synthetic Cannabinoid, Induces Addiction-Related Behaviors through Neurochemical Maladaptation in the Brain of Rodents.Pharmaceuticals (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeIn the present study we characterized a series of synthetic cannabinoids containing various heterocyclic scaffolds that had been identified as constituents of "Spice", a preparation sold on the illicit drug market. All compounds were further investigated as potential ligands of the orphan receptors GPR18 and GPR55 that interact with some cannabinoids.
methodsThe compounds were studied in radioligand binding assays to determine their affinity for human cannabinoid CB
resultsStructure-activity relationships were analyzed. The most potent CB
conclusionsThese results will be useful to assess the compounds' toxicological risks and to guide legislation. Further studies on
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.