ArticleOncology letters2018
Analysis of the complex interaction of CDR1as-miRNA-protein and detection of its novel role in melanoma.
Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The Prognostic and Predictive Significance of circRNA CDR1as in Tumor Progression.Frontiers in oncology · 2020Pooled it
- The Role of Non-coding RNAs in Tumorigenesis, Diagnosis/Prognosis, and Therapeutic Strategies for Cutaneous Melanoma.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Exosomal Non-coding RNAs: A New Approach to Melanoma Diagnosis and Therapeutic Strategy.Current medicinal chemistry · 2024Review
- Rheumatoid arthritis fibroblast-like synoviocytes maintain tumor-like biological characteristics through ciRS-7-dependent regulation of miR-7.Molecular biology reports · 2022Article
- CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers.International journal of biological sciences · 2021Review
- Article
- Biogenesis, Features, Functions, and Disease Relationships of a Specific Circular RNA: CDR1as.Aging and disease · 2020Review
- Circular RNAs: epigenetic regulators in cancerous and noncancerous skin diseases.Cancer gene therapy · 2020Review
- Disease-Associated Circular RNAs: From Biology to Computational Identification.BioMed research international · 2020Review
- The Emerging Picture of the Roles of CircRNA-CDR1as in Cancer.Frontiers in cell and developmental biology · 2020Review
- circRNA CDR1as Regulated the Proliferation of Human Periodontal Ligament Stem Cells under a Lipopolysaccharide-Induced Inflammatory Condition.Mediators of inflammation · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite improvements in the prevention, diagnosis and treatment of melanoma having developed rapidly, the role of circular RNA CDR1 antisense RNA (CDR1as) in melanoma remains to be elucidated. The aim of the present study was to predict the novel roles of CDR1as in melanoma through novel bioinformatics analysis. In the present study, the circ2Traits database was used to supply information on CDR1as in cancer. CircNet, circBase and circInteractome databases were used to detect the co-expression of CDR1as, microRNAs and proteins. Furthermore, the functions and pathways of the associated proteins were predicted using the Database for Annotation, Visualization and Integrated Discovery. Gene Ontology enrichment analysis suggested that the proteins associated with CDR1as were mainly regulated in the cytoplasm as the molecular protein binding, the biological process of cell division and the endoplasmic reticulum tubular network, which are all involved in cancer-related processes. The Kyoto Encyclopedia of Genes and Genome pathway cell cycle was closely associated with the location of cancer. Co-expression network analysis revealed the associations among CDR1as, microRNAs and proteins. The bioinformatics analysis showed that CDR1as may act as the competing endogenous RNA for the vital genes, which are associated with the invasion and migration of melanoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.