Evidence map›Paper›PMID 29963112›Full record

ArticleJournal of breast cancer2018

Genetic Variants Associated with Clinicopathological Profiles in Sporadic Breast Cancer in Sri Lankan Women.

Nirmala Dushyanthi Sirisena, Adebowale Adeyemo, Anchala Ishani Kuruppu, Nilakshi Samaranayake, Vajira Harshadeva Weerabaddana Dissanayake

Open access · goldAbstract read
In one paragraph

Article in Journal of breast cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Exploratory Association of 5' and 3' UTRs Variants inInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Review
  5. Association of Gene Polymorphisms with Breast Cancer Risk in the Kazakh Population.Asian Pacific journal of cancer prevention : APJCP · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Pharmacogenomics and personalized medicine · 2021
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nirmala Dushyanthi SirisenaHuman Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Adebowale AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, USA.
Anchala Ishani KuruppuHuman Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Nilakshi SamaranayakeDepartment of Parasitology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Vajira Harshadeva Weerabaddana DissanayakeHuman Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
University of Colombo · LKNational Human Genome Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSeveral single nucleotide polymorphisms (SNPs) have been reported to be associated with clinicopathological profiles in sporadic breast cancer based on studies conducted on major population groups. The knowledge of the effects of these common genetic variants in South Asian populations remains limited. The present study aimed to investigate the association between a selected set of SNPs and the clinicopathological profiles in sporadic breast cancer in Sri Lankan women.

methodsA total of 350 postmenopausal women with histologically confirmed invasive breast cancer were genotyped for 58 SNPs located in 36 breast cancer related genes. The clinicopathological factors that were investigated included age of onset, tumor histologic grade, and lymph node involvement, as well as estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2 (HER2) status. Association testing was performed using logistic regression models adjusted for confounding factors.

resultsSeven SNPs showed significant associations with clinicopathological profiles in breast cancer. The G allele of

conclusionThe common genetic variants identified in the

Indexed as

AllelesBreast neoplasmsPostmenopausePrognosisSingle nucleotide polymorphism

Identifiers

PMID29963112
PMCPMC6015979
OpenAlexW2809119443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.