Evidence map›Paper›PMID 29963090›Full record

ArticleIranian journal of parasitology

Trypanocidal Effects of Cisplatin alone and in Combination with

Nashaat Abd El-Monem Nassef, Manal Ahmed El-Melegy, Engy Victor Beshay, Dalia Rifaat Al-Sharaky, Tahany Mohamed Al-Attar

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In one paragraph

Article in Iranian journal of parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nashaat Abd El-Monem NassefMedical Parasitology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Manal Ahmed El-MelegyMedical Parasitology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Engy Victor BeshayMedical Parasitology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Dalia Rifaat Al-SharakyPathology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Tahany Mohamed Al-AttarMedical Parasitology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Menoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDue to the limited number of the available drugs for the treatment of trypanosomiasis, this study was designed to evaluate the trypanocidal effects of cisplatin or/and

methodsDuring 2015 at the Parasitology Department, Menoufia University, Menoufia, Egypt, sixty Swiss albino mice were divided into six groups: normal control (I), infected control (II); cisplatin-treated (III); NSO-treated (IV); combined cisplatin + NSO-treated (V) and diminazene-treated (VI). The tested drugs were evaluated by the assessment of parasitaemia, measurement of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, serum IgM and a histopathological study.

resultsNSO showed a trypanocidal effect, however; it was not as effective as cisplatin or diminazene. There were significant increases of AST, ALT, urea, and creatinine in group II and III, which were significantly reduced in cisplatin + NSO-treated group (V). Moreover, there were significant reductions in serum IgM and the pathological changes of the examined organs of group V when they were compared with other treated groups.

conclusionCisplatin combined with NSO showed a trypanocidal effect against

Indexed as

CisplatinDiminazeneMiceN. sativaT. evansiTrypanocidal

Identifiers

PMID29963090
PMCPMC6019580
OpenAlexW2791608652

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.