Evidence map›Paper›PMID 29963073›Full record

ArticleFrontiers in genetics2018

Combining Pathway Identification and Breast Cancer Survival Prediction via Screening-Network Methods.

Antonella Iuliano, Annalisa Occhipinti, Claudia Angelini, Italia De Feis, Pietro Liò

Abstract read
In one paragraph

Article in Frontiers in genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Antonella IulianoIstituto per le Applicazioni del Calcolo "Mauro Picone", Consiglio Nazionale delle Ricerche, Naples, Italy.
Annalisa OcchipintiComputer Laboratory, University of Cambridge, Cambridge, United Kingdom.
Claudia AngeliniIstituto per le Applicazioni del Calcolo "Mauro Picone", Consiglio Nazionale delle Ricerche, Naples, Italy.
Italia De FeisIstituto per le Applicazioni del Calcolo "Mauro Picone", Consiglio Nazionale delle Ricerche, Naples, Italy.
Pietro LiòComputer Laboratory, University of Cambridge, Cambridge, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is one of the most common invasive tumors causing high mortality among women. It is characterized by high heterogeneity regarding its biological and clinical characteristics. Several high-throughput assays have been used to collect genome-wide information for many patients in large collaborative studies. This knowledge has improved our understanding of its biology and led to new methods of diagnosing and treating the disease. In particular, system biology has become a valid approach to obtain better insights into breast cancer biological mechanisms. A crucial component of current research lies in identifying novel biomarkers that can be predictive for breast cancer patient prognosis on the basis of the molecular signature of the tumor sample. However, the high dimension and low sample size of data greatly increase the difficulty of cancer survival analysis demanding for the development of

Indexed as

breast cancercox regressionhigh-dimensionalitynetwork-penalized methodspathway analysisscreening techniquessurvival analysis

Identifiers

PMID29963073
PMCPMC6011013

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.