Evidence map›Paper›PMID 29963053›Full record

ArticleFrontiers in immunology2018

Long-Term Clinical and Immunological Profile of Kidney Transplant Patients Given Mesenchymal Stromal Cell Immunotherapy.

Norberto Perico, Federica Casiraghi, Marta Todeschini, Monica Cortinovis, Eliana Gotti, Valentina Portalupi, Marilena Mister, Flavio Gaspari, Alessandro Villa, Sonia Fiori and 3 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Autologous bone marrow-derived mesenchymal stromal cell therapy with early tacrolimus withdrawal: The randomized prospective, single-center, open-label TRITON study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
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  11. From AKI to CKD: Maladaptive Repair and the Underlying Mechanisms.International journal of molecular sciences · 2022
    Review
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  16. Ex Vivo Mesenchymal Stem Cell Therapy to Regenerate Machine Perfused Organs.International journal of molecular sciences · 2021
    Review
  17. Review
  18. Review
  19. Cellular therapies in organ transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Norberto PericoIRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Federica CasiraghiIRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Marta TodeschiniIRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Monica CortinovisIRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Eliana GottiUnit of Nephrology and Dialysis, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Valentina PortalupiUnit of Nephrology and Dialysis, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Marilena MisterIRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Flavio GaspariIRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Alessandro VillaIRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Sonia FioriIRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
Martino IntronaG. Lanzani Laboratory of Cell Therapy, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Elena LonghiLaboratory of Transplant Immunology, UOC Coordinamento Trapianti IRCCS Fondazione Ca' Granda - Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Giuseppe RemuzziIRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report here the long-term clinical and immunological results of four living-donor kidney transplant patients given autologous bone marrow-derived mesenchymal stromal cells (MSCs) as part of a phase 1 study focused on the safety and feasibility of this cell therapy. According to study protocols implemented over time, based on initial early safety findings, the patients were given MSC at day 7 posttransplant (

Indexed as

B cellskidney transplantationmemory CD8+ T cellsmesenchymal stromal cellsregulatory T cellstolerance

Identifiers

PMID29963053
PMCPMC6014158

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.