Evidence map›Paper›PMID 29963042›Full record

ArticleFrontiers in immunology2018

Functional Characterisation and Analysis of the Soluble NKG2D Ligand Repertoire Detected in Umbilical Cord Blood Plasma.

Steven T Cox, Robert Danby, Diana Hernandez, Raquel Laza-Briviesca, Hayley Pearson, J Alejandro Madrigal, Aurore Saudemont

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Association of ProtectiveFrontiers in genetics · 2021
    Article
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  7. Article
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  10. Cord Blood-Derived Platelet Gel in Wound Healing: From Biological Rationale to Clinical Application.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Steven T CoxAnthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom.
Robert DanbyAnthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom.
Diana HernandezAnthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom.
Raquel Laza-BriviescaAnthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom.
Hayley PearsonAnthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom.
J Alejandro MadrigalAnthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom.
Aurore SaudemontAnthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom.
Anthony Nolan · GBThe Royal Free Hospital · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously reported that cord blood plasma (CBP) contains significantly more soluble NKG2D ligands (sNKG2DLs), such as sMICB and sULBP1, than healthy adult plasma. Viral infection or malignant transformation upregulates expression of NKG2D ligand on affected cells, leading to NK group 2, member D (NKG2D)-mediated natural killer (NK) cell lysis. Conversely, sNKG2DL engagement of NKG2D decreases NK cell cytotoxicity leading to viral or tumour immune escape. We hypothesised that sNKG2DLs detected in CBP may represent an additional fetal-maternal tolerance mechanism. To further understand the role of sNKG2DL in pregnancy and individual contributions of the various ligand types, we carried out functional analysis using 181 CBP samples. To test the ability of CBP to suppress the function of NK cells

Indexed as

Fetal BloodLigands3' Untranslated RegionsBiomarkersCytotoxicity, ImmunologicFemaleGene ExpressionGPI-Linked ProteinsHistocompatibility Antigens Class IHumansImmunity, InnateInterferon-gammaIntracellular Signaling Peptides and ProteinsKiller Cells, NaturalLymphocyte ActivationMale3' Untranslated RegionsBiomarkersGPI-Linked ProteinsHistocompatibility Antigens Class IInterferon-gammaIntracellular Signaling Peptides and ProteinsLigandsMHC class I-related chain AMICB antigenNK Cell Lectin-Like Receptor Subfamily KULBP1 protein, humanligandluciferaseMICANK cellNKG2DpregnancytoleranceULBP1

Identifiers

PMID29963042
PMCPMC6013648
OpenAlexW2808530558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.