Evidence map›Paper›PMID 29963041›Full record

ArticleFrontiers in immunology2018

Toll-Like Receptor 4 Triggering Promotes Cytosolic Routing of DC-SIGN-Targeted Antigens for Presentation on MHC Class I.

Sophie K Horrevorts, Sanne Duinkerken, Karien Bloem, Pablo Secades, Hakan Kalay, René J Musters, Sandra J van Vliet, Juan J García-Vallejo, Yvette van Kooyk

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Cross-presentation of citrullinated antigens drives cytotoxic CD8bioRxiv : the preprint server for biology · 2026
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  17. Selective tumor antigen vaccine delivery to human CD169Proceedings of the National Academy of Sciences of the United States of America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sophie K HorrevortsDepartment of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands.
Sanne DuinkerkenDepartment of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands.
Karien BloemDepartment of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands.
Pablo SecadesDivision of Cell Biology, Dutch Cancer Institute, Amsterdam, Netherlands.
Hakan KalayDepartment of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands.
René J MustersDepartment of Physiology, VU University Medical Center, Amsterdam, Netherlands.
Sandra J van VlietDepartment of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands.
Juan J García-VallejoDepartment of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands.
Yvette van KooykDepartment of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands.
Amsterdam UMC Location VUmc · NLNutricia Research (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DC-SIGN is an antigen uptake receptor expressed on dendritic cells (DCs) with specificity for glycans present on a broad variety of pathogens and is capable of directing its cargo to MHC-I and MHC-II pathways for the induction of CD8

Indexed as

Antigen PresentationAntigensBiomarkersCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Adhesion MoleculesCell MembraneCross-PrimingDC-Specific ICAM-3 Grabbing NonintegrinEndosomesHistocompatibility Antigens Class IHumansLectins, C-TypeProtein BindingProtein TransportReceptors, Cell SurfaceAntigensBiomarkersCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinHistocompatibility Antigens Class ILectins, C-TypeReceptors, Cell SurfaceToll-Like Receptor 4cross-presentationDC-SIGNdendritic cellsimaging flow cytometryMHC-IproteasomeT celltoll-like receptor

Identifiers

PMID29963041
PMCPMC6010527
OpenAlexW2803987567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.