Evidence map›Paper›PMID 29963040›Full record

ArticleFrontiers in immunology2018

CD19

María Molina, Luis M Allende, Luis E Ramos, Eduardo Gutiérrez, Daniel E Pleguezuelo, Eduardo R Hernández, Francisco Ríos, Cristina Fernández, Manuel Praga, Enrique Morales

Abstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. Lower absolute numbers of CD4Renal failure · 2025
    Article
  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

María MolinaDepartment of Nephrology, Hospital Universitario 12 de Octubre and Research Institute i+12, Madrid, Spain.
Luis M AllendeDepartment of Immunology, Hospital Universitario 12 de Octubre and Research Institute i+12, Madrid, Spain.
Luis E RamosDepartment of Nephrology, Hospital Universitario 12 de Octubre and Research Institute i+12, Madrid, Spain.
Eduardo GutiérrezDepartment of Nephrology, Hospital Universitario 12 de Octubre and Research Institute i+12, Madrid, Spain.
Daniel E PleguezueloDepartment of Immunology, Hospital Universitario 12 de Octubre and Research Institute i+12, Madrid, Spain.
Eduardo R HernándezDepartment of Nephrology, Hospital Universitario 12 de Octubre and Research Institute i+12, Madrid, Spain.
Francisco RíosSan Luciano Hemodialysis Unit, Fresenius Medical Care, Madrid, Spain.
Cristina FernándezDepartment of Epidemiology and Preventive Medicine, Hospital Universitario Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain.
Manuel PragaDepartment of Nephrology, Hospital Universitario 12 de Octubre and Research Institute i+12, Madrid, Spain.
Enrique MoralesDepartment of Nephrology, Hospital Universitario 12 de Octubre and Research Institute i+12, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: Mortality of patients on hemodialysis (HD) remains very high despite recent improvements in HD techniques. Cardiovascular (CV) complications and infections are the main causes of death. Some studies suggest that disturbances in the immune system could play a role in this disproportionate mortality, through the links of immunity with inflammation and propensity to infections. However, few studies have addressed the role of lymphocyte populations and the global and CV mortality of HD patients. Aim: To analyze the relationship of peripheral blood lymphocyte populations (PBLP) and all-cause and CV mortality of HD patients. Design setting participants and measurements: We design a prospective observational single center study in a cohort of HD prevalent patients. PBLP were analyzed at baseline and after 1 year and patients were followed for a 5-year period. Main outcomes were all-cause and CV mortality. Results: One hundred and four patients (51% male, mean age 64.8 ± 15 years) were included. Follow-up was 18 (7-47) months. Fifty-five patients (52.8%) died, main causes of death being CVD (40%) and infections (29.1%). Low total lymphocyte counts were found in 47 patients (45.2%), and the most frequency lymphopenias were CD19 Conclusion: CD19

Indexed as

BiomarkersLymphocyte CountAgedAged, 80 and overAntigens, CD19B-LymphocytesCause of DeathComplement System ProteinsFemaleHumansImmunoglobulinsKaplan-Meier EstimateKidney Failure, ChronicMaleMiddle AgedMortalityAntigens, CD19BiomarkersComplement System ProteinsImmunoglobulinsB-cellscardiovascular diseasehemodialysislymphocytesmortality

Identifiers

PMID29963040
PMCPMC6013647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.