Evidence map›Paper›PMID 29963017›Full record

ArticleFrontiers in microbiology2018

Oral Delivery of Nisin in Resistant Starch Based Matrices Alters the Gut Microbiota in Mice.

Ronan Gough, Raúl Cabrera Rubio, Paula M O'Connor, Fiona Crispie, André Brodkorb, Song Miao, Colin Hill, Reynolds P Ross, Paul D Cotter, Kanishka N Nilaweera and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ronan GoughTeagasc Food Research Centre, Fermoy, Ireland.
Raúl Cabrera RubioTeagasc Food Research Centre, Fermoy, Ireland.
Paula M O'ConnorTeagasc Food Research Centre, Fermoy, Ireland.
Fiona CrispieTeagasc Food Research Centre, Fermoy, Ireland.
André BrodkorbTeagasc Food Research Centre, Fermoy, Ireland.
Song MiaoTeagasc Food Research Centre, Fermoy, Ireland.
Colin HillSchool of Microbiology, University College Cork, Cork, Ireland.
Reynolds P RossAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Paul D CotterTeagasc Food Research Centre, Fermoy, Ireland.
Kanishka N NilaweeraTeagasc Food Research Centre, Fermoy, Ireland.
Mary C ReaTeagasc Food Research Centre, Fermoy, Ireland.
Teagasc - The Irish Agriculture and Food Development Authority · IEAPC Microbiome Institute · IEUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a growing recognition of the role the gastrointestinal microbiota plays in health and disease. Ingested antimicrobial proteins and peptides have the potential to alter the gastrointestinal microbiota; particularly if protected from digestion. Nisin is an antimicrobial peptide that is used as a food preservative. This study examined the ability of nisin to affect the murine microbiota when fed to mice in two different starch based matrices; a starch dough comprising raw starch granules and a starch gel comprising starch that was gelatinized and retrograded. The effects of the two starch matrices by themselves on the microbiota were also examined. Following 16S rRNA compositional sequencing, beta diversity analysis highlighted a significant difference (

Indexed as

Akkermansiadigestionmicrobiotamousenisinresistant starchstarch

Identifiers

PMID29963017
PMCPMC6013561
OpenAlexW2806720197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.