Evidence map›Paper›PMID 29963011›Full record

ArticleFrontiers in endocrinology2018

Double Stimulation in the Same Ovarian Cycle (DuoStim) to Maximize the Number of Oocytes Retrieved From Poor Prognosis Patients: A Multicenter Experience and SWOT Analysis.

Alberto Vaiarelli, Danilo Cimadomo, Elisabetta Trabucco, Roberta Vallefuoco, Laura Buffo, Ludovica Dusi, Fabrizio Fiorini, Nicoletta Barnocchi, Francesco Maria Bulletti, Laura Rienzi and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05815719 (Continuous Ovarian Stimulation in DUOSTIM Cycles.), which is not on this map. Cited by 47 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05815719 phase4completednot on this mapstarted 2022, after this paper: background citation

Continuous Ovarian Stimulation in DUOSTIM Cycles.

TypeinterventionalSponsorInstituto BernabeuRan2022 to 2023Enrolled30ConditionsFertility IssuesArmsCorifollitropin Alfa, Follitropin Alfa, Follitropin Alfa Biosimilar, Urinary Human follicle stimulating hormone
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Luteal phase stimulation versus follicular phase stimulation in poor ovarian responders: A systematic review and a meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
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  19. ComparisonInternational journal of fertility & sterility · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alberto VaiarelliClinica Valle Giulia, G.en.e.r.a. Centers for Reproductive Medicine, Rome, Italy.
Danilo CimadomoClinica Valle Giulia, G.en.e.r.a. Centers for Reproductive Medicine, Rome, Italy.
Elisabetta TrabuccoClinica Ruesch, G.en.e.r.a. Centers for Reproductive Medicine, Naples, Italy.
Roberta VallefuocoClinica Ruesch, G.en.e.r.a. Centers for Reproductive Medicine, Naples, Italy.
Laura BuffoG.en.e.r.a. Veneto, G.en.e.r.a. Centers for Reproductive Medicine, Marostica, Italy.
Ludovica DusiG.en.e.r.a. Veneto, G.en.e.r.a. Centers for Reproductive Medicine, Marostica, Italy.
Fabrizio FioriniG.en.e.r.a. Umbria, G.en.e.r.a. Centers for Reproductive Medicine, Umbertide, Italy.
Nicoletta BarnocchiG.en.e.r.a. Umbria, G.en.e.r.a. Centers for Reproductive Medicine, Umbertide, Italy.
Francesco Maria BullettiUniversity of Targu Mures, Targu Mures, Romania.
Laura RienziClinica Valle Giulia, G.en.e.r.a. Centers for Reproductive Medicine, Rome, Italy.
Filippo Maria UbaldiClinica Valle Giulia, G.en.e.r.a. Centers for Reproductive Medicine, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A panel of experts known as the POSEIDON group has recently redefined the spectrum of poor responder patients and introduced the concept of suboptimal response. Since an ideal management for these patients is still missing, they highlighted the importance of tailoring the ovarian stimulation based on the chance of each woman to obtain an euploid blastocyst. Interestingly, a novel pattern of follicle recruitment has been defined: multiple waves may arise during a single ovarian cycle. This evidence opened important clinical implications for the treatment of poor responders. For instance, double stimulation in the follicular (FPS) and luteal phase (LPS) of the same ovarian cycle (DuoStim) is an intriguing option to perform two oocyte retrievals in the shortest possible time. Here, we reported our 2-year experience of DuoStim application in four private IVF centers. To date, 310 poor prognosis patients completed a DuoStim protocol and underwent IVF with blastocyst-stage preimplantation-genetic-testing. LPS resulted into a higher mean number of oocytes collected than FPS; however, their competence (i.e., fertilization, blastocyst, euploidy rates, and clinical outcomes after euploid single-embryo-transfer) was comparable. Importantly, the rate of patients obtaining at least one euploid blastocyst increased from 42.3% (

Indexed as

double stimulationdual-stimulationduostimeuploid blastocystIVFlow prognosis patientspoor responderPoseidon

Identifiers

PMID29963011
PMCPMC6010525

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.