ArticleFrontiers in psychiatry2018
Unraveling the Genetic and Environmental Relationship Between Well-Being and Depressive Symptoms Throughout the Lifespan.
Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-analysis.JAMA psychiatry · 2020Pooled it
- Living happily ever after: longitudinal insights into enduring mental health and wellbeing.Social psychiatry and psychiatric epidemiology · 2026Article
- Stability and Change in Wellbeing Throughout Adolescence and Its Relationship with Life Events: A Longitudinal Twin Study.Behavior genetics · 2026Article
- Article
- The Association Between Frequency of Social Media Use, Wellbeing, and Depressive Symptoms: Disentangling Genetic and Environmental Factors.Behavior genetics · 2025Article
- Child Wellbeing during the COVID-19 Pandemic: A Multi-cohort Comparison and a Multi-informant Genetic Study.Behavior genetics · 2025Article
- The association between metabolite concentrations and wellbeing in adults.Scientific reports · 2025Article
- Preliminary Evidence for Genetic Nurture in Depression and Neuroticism Through Polygenic Scores.JAMA psychiatry · 2023Article
- Epigenomic Links Between Social Determinants of Health and Symptoms: A Scoping Review.Biological research for nursing · 2023Article
- Genetic propensity, socioeconomic status, and trajectories of depression over a course of 14 years in older adults.Translational psychiatry · 2023Article
- Key Predictive Factors in the Mental Health of Chinese University Students at Home and Abroad.International journal of environmental research and public health · 2022Article
- Article
- Negative and Positive Psychosocial Factors in Relation to Cognitive Health in Older African Americans.Innovation in aging · 2022Article
- Genetic Influences on the Covariance and Genetic Correlations in a Bivariate Twin Model: An Application to Well-Being.Behavior genetics · 2021Article
- Functional plasticity abnormalities over the lifespan of first-episode patients with major depressive disorder: a resting state fMRI study.Annals of translational medicine · 2021Article
- A Comparison of the ASEBA Adult Self Report (ASR) and the Brief Problem Monitor (BPM/18-59).Behavior genetics · 2020Article
- Psychological well-being as part of the public health debate? Insight into dimensions, interventions, and policy.BMC public health · 2019Review
- Spotlight on eudaimonia and depression. A systematic review of the literature over the past 5 years.Psychology research and behavior management · 2019Article
- The Relationship Between Satisfaction With Life and Depression Symptoms by Gender.Frontiers in psychiatry · 2019Article
- A genetic perspective on the relationship between eudaimonic -and hedonic well-being.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Whether well-being and depressive symptoms can be considered as two sides of the same coin is widely debated. The aim of this study was to gain insight into the etiology of the association between well-being and depressive symptoms across the lifespan. In a large twin-design, including data from 43,427 twins between age 7 and 99, we estimated the association between well-being and depressive symptoms throughout the lifespan and assessed genetic and environmental contributions to the observed overlap. For both well-being (range 31-47%) and depressive symptoms (range 49-61%), genetic factors explained a substantial part of the phenotypic variance across the lifespan. Phenotypic correlations between well-being and depressive symptoms across ages ranged from -0.34 in childhood to -0.49 in adulthood. In children, genetic effects explained 49% of the phenotypic correlation while in adolescents and young adults, genetic effects explained 60-77% of the phenotypic correlations. Moderate to high genetic correlations (ranging from -0.59 to -0.66) were observed in adolescence and adulthood, while in childhood environmental correlations were substantial but genetic correlations small. Our results suggest that in childhood genetic and environmental effects are about equally important in explaining the relationship between well-being and depressive symptoms. From adolescence onwards, the role of genetic effects increases compared to environmental effects. These results provided more insights into the etiological underpinnings of well-being and depressive symptoms, possibly allowing to articulate better strategies for health promotion and resource allocation in the future.
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