Evidence map›Paper›PMID 29962961›Full record

ArticleFrontiers in physiology2018

Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium.

Marine E Martinez, Richard D Walton, Jason D Bayer, Michel Haïssaguerre, Edward J Vigmond, Mélèze Hocini, Olivier Bernus

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Mapping and ablation of ventricular fibrillation substrate.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Review
  2. Electrocardiographic markers of arrhythmogenic risk in patients with isolated coronary artery ectasia.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Impact of intraventricular septal fiber orientation on cardiac electromechanical function.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  8. Article
  9. ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Marine E MartinezCentre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France.
Richard D WaltonCentre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France.
Jason D BayerCentre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France.
Michel HaïssaguerreCentre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France.
Edward J VigmondCentre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France.
Mélèze HociniCentre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France.
Olivier BernusCentre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France.
Centre Hospitalier Universitaire de Bordeaux · FRInstitut de Mathématiques de Bordeaux · FRCentre de Recherche Cardio-Thoracique de Bordeaux · FRInserm · FRUniversité de Bordeaux · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alteration of action potential duration (APD) heterogeneity contributes to arrhythmogenesis. Purkinje-muscle junctions (PMJs) present differential electrophysiological properties including longer APD. The goal of this study was to determine if Purkinje-related or myocardial focal activation modulates ventricular repolarization differentially in healthy and ischemic myocardium. Simultaneous epicardial (EPI) and endocardial (ENDO) optical mapping was performed on sheep left ventricular (LV) wedges with intact free-running Purkinje network (

Indexed as

activation sequenceoptical mappingPurkinje-muscle junctionrepolarizationtransmural heterogeneity

Identifiers

PMID29962961
PMCPMC6010581
OpenAlexW2803747712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.