Evidence map›Paper›PMID 29962936›Full record

ReviewFrontiers in cellular neuroscience2018

Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research.

Zoé Christenson Wick, Esther Krook-Magnuson

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Optogenetics in Alzheimer's Disease: Focus on Astrocytes.Antioxidants (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. The cerebellum and epilepsy.Epilepsy & behavior : E&B · 2021
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zoé Christenson WickGraduate Program in Neuroscience and Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States.
Esther Krook-MagnusonGraduate Program in Neuroscience and Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States.
University of Minnesota · US

Funding

PREDOCTORAL TRAINING OF NEUROSCIENTISTST32GM008471 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI EBNER, TIMOTHY J · 1993 to 2017
$4.9M
A novel inhibitory target for temporal lobe epilepsyR01NS104071 · NINDS · UNIVERSITY OF MINNESOTA · PI KROOK-MAGNUSON, ESTHER · 2018 to 2022
$1.6M
On-demand optogenetic cerebellar intervention for temporal lobe epilepsyR00NS087110 · NINDS · UNIVERSITY OF MINNESOTA · PI KROOK-MAGNUSON, ESTHER · 2015 to 2017
$747k
Targeting the ventral hippocampus for a better model of temporal lobe epilepsyR03NS098015 · NINDS · UNIVERSITY OF MINNESOTA · PI KROOK-MAGNUSON, ESTHER · 2016 to 2017
$153k
NIGMS NIH HHS T32 GM008471NINDS NIH HHS R00 NS087110NINDS NIH HHS R01 NS104071NINDS NIH HHS R03 NS098015
6 · The paper itself

Abstract

Optogenetics is a powerful and rapidly expanding set of techniques that use genetically encoded light sensitive proteins such as opsins. Through the selective expression of these exogenous light-sensitive proteins, researchers gain the ability to modulate neuronal activity, intracellular signaling pathways, or gene expression with spatial, directional, temporal, and cell-type specificity. Optogenetics provides a versatile toolbox and has significantly advanced a variety of neuroscience fields. In this review, using recent epilepsy research as a focal point, we highlight how the specificity, versatility, and continual development of new optogenetic related tools advances our understanding of neuronal circuits and neurological disorders. We additionally provide a brief overview of some currently available optogenetic tools including for the selective expression of opsins.

Indexed as

archaerhodopsincell type specificitychannelrhodopsinhalorhodopsinintersectional geneticsneuronal circuitryparvalbuminseizures

Identifiers

PMID29962936
PMCPMC6010559
OpenAlexW2804389727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.