ArticleKorean journal of radiology
The Diagnostic Performance of Liver MRI without Intravenous Contrast for Detecting Hepatocellular Carcinoma: A Case-Controlled Feasibility Study.
Article in Korean journal of radiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Non-Contrast MRI for Hepatocellular Carcinoma Surveillance and Diagnosis: A Systematic Review and Meta-Analysis of Diagnostic Accuracy.Journal of medical imaging and radiation oncology · 2026Pooled it
- Inter-reader agreement of abbreviated magnetic resonance imaging for hepatocellular carcinoma detection: a systematic review and meta-analysis.Abdominal radiology (New York) · 2022Pooled it
- Deep Learning-Accelerated Non-Contrast Abbreviated Liver MRI for Detecting Malignant Focal Hepatic Lesions: Dual-Center Validation.Korean journal of radiology · 2025Article
- Recent advances and issues in imaging modalities for hepatocellular carcinoma surveillance.Journal of liver cancer · 2025Article
- Optimizing Hepatocellular Carcinoma Screening: A Comparative Simulated Abbreviated MRI Protocol Study.Cureus · 2025Article
- Deep learning-assisted diagnosis of liver tumors using non-contrast magnetic resonance imaging: a multicenter study.Frontiers in oncology · 2025Article
- Abbreviated magnetic resonance imaging in hepatocellular carcinoma surveillance: A review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Non-contrast abbreviated MRI for the detection of hepatocellular carcinoma in patients with Liver Imaging Reporting and Data System LR-3 and LR-4 observations in MRI.The British journal of radiology · 2024Article
- Article
- Estimating postsurgical outcomes of patients with a single hepatocellular carcinoma using gadoxetic acid-enhanced MRI: risk scoring system development and validation.European radiology · 2023Article
- The feasibility of superparamagnetic iron oxide-enhanced magnetic resonance imaging for assessing liver lesions in patients with contraindications for iodine CT contrast media or gadolinium-based MR contrast media: a retrospective case-control study.Quantitative imaging in medicine and surgery · 2022Article
- Imaging diagnosis of hepatocellular carcinoma: Future directions with special emphasis on hepatobiliary magnetic resonance imaging and contrast-enhanced ultrasound.Clinical and molecular hepatology · 2022Review
- Evaluation of non-contrast magnetic resonance imaging as an imaging surveillance tool for hepatocellular carcinoma in at-risk patients.Singapore medical journal · 2022Article
- Diagnostic Performance of Simulated Abbreviated MRI for Early-Stage Hepatocellular Carcinoma Screening: A Comparison to Conventional Dynamic Contrast-Enhanced MRI.Taehan Yongsang Uihakhoe chi · 2021Article
- Abbreviated MR Protocols for Chronic Liver Disease and Liver Cancer.Magnetic resonance imaging clinics of North America · 2021Review
- Review
- Assessment of SE-MRE-derived shear stiffness at 3.0 Tesla for solid liver tumors characterization.Abdominal radiology (New York) · 2021Article
- Abbreviated MRI Protocol for the Assessment of Ablated Area in HCC Patients.International journal of environmental research and public health · 2021Article
- [Recent Updates of Abbreviated MRI for Hepatocellular Carcinoma Screening].Taehan Yongsang Uihakhoe chi · 2021Review
- Current status of image-based surveillance in hepatocellular carcinoma.Ultrasonography (Seoul, Korea) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To preliminarily evaluate the diagnostic performance of an unenhanced MRI for detecting hepatocellular carcinoma (HCC) with a case-control study design. Materials and Methods: The case group consisted of 175 patients with initially-diagnosed HCC, who underwent a 3T liver MRI. A total of 237 HCCs were identified. The number of HCCs that were smaller than 1 cm, 1 cm ≤ and < 2 cm, and ≥ 2 cm were 19, 105, and 113, respectively. For the control group, 72 patients with chronic liver disease, who did not have HCC, were enrolled. Two radiologists independently reviewed the T2 half-Fourier acquisition single-shot turbo spin echo, T2 fast spin echos with fat saturation, T1 gradient in- and out-of-phase images, and diffusion-weighted images/apparent diffusion coefficient maps to detect HCC. Per-patient analyses were performed to evaluate the sensitivity and specificity of the non-contrast MRI for diagnosing HCC. Furthermore, the per-lesion sensitivity was also calculated according to tumor size. Results: In the per-patient analyses, the sensitivity and specificity of reader 1 were 86.3% (151/175) and 87.5% (63/72), respectively; while those of reader 2 were 82.9% (145/175) and 76.4% (55/72), respectively. When excluding HCCs smaller than 1 cm, the sensitivity of reader 1 and 2 were 88.0% (147/167) and 86.2% (144/167), respectively. In the per-lesion analyses, the sensitivities of reader 1 and reader 2 were 75.9% (180/237) and 70.5% (167/237), respectively. Conclusion: The per-patient sensitivity and specificity of non-contrast MRIs were within a reasonable range for the initial diagnosis of HCC. Non-contrast MRIs may have a potential for surveillance of HCC. Further confirmatory diagnostic test accuracy studies are needed.
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