ArticleContemporary clinical dentistry2018
Characterization of Herbal Antifungal Agent,
Article in Contemporary clinical dentistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Dual-Loaded Galangal Extract and Lemongrass Oil Biobased Self-Emulsifying System for Denture-Cleansing Applications.ACS omega · 2026Article
- In vitro antifungal activities of medicinal plants used for treatment of candidiasis in Pader district, Northern Uganda.Tropical medicine and health · 2024Article
- Identification of compounds fromSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Evaluation of Chemical Profile and Biological Properties of Extracts of DifferentInternational journal of molecular sciences · 2024Article
- The inhibitory effects of carvacrol, nystatin, and their combination on oral candidiasis isolates.BMC research notes · 2024Article
- Article
- Efficacy of Various Herbal Preparations Against Oral Candida: A Lab-Based Study.Journal of pharmacy & bioallied sciences · 2024Article
- Antioxidant and Antibacterial Activity of Mexican Oregano Essential Oil, Extracted from Plants Occurring Naturally in Semiarid Areas and Cultivated in the Field and Greenhouse in Northern Mexico.Molecules (Basel, Switzerland) · 2023Article
- Antibacterial activity of oregano essential oils against Streptococcus mutans in vitro and analysis of active components.BMC complementary medicine and therapies · 2023Article
- Origanum vulgare L. essential oil inhibits virulence patterns of Candida spp. and potentiates the effects of fluconazole and nystatin in vitro.BMC complementary medicine and therapies · 2022Article
- Article
- Clinical applications of antimicrobial photodynamic therapy in dentistry.Frontiers in microbiology · 2022Review
- Efficacy of Toluidine Blue-Mediated Antimicrobial Photodynamic Therapy onAntibiotics (Basel, Switzerland) · 2021Review
- A Review of the Phytochemistry and Antimicrobial Properties ofIranian journal of pharmaceutical research : IJPR · 2021Review
- Chemical profiling, biostatic and biocidal dynamics of Origanum vulgare L. essential oil.AMB Express · 2019Article
- Evaluation of the antifungal efficacy of different concentrations ofJournal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCandida Associated Denture Stomatitis is the prevalent fungal pathosis in denture wearers, especially in immunocompromized patients. Existing antifungal agents are ineffective since the Candida species become resistant and also, they become toxic. Origanum vulgare is a herbal plant with high anti-fungal activity against Candida of blood and urine origin. However, it has never been explored against Candida from oral cavity. MATERIALS & METHODOLOGY: Dry leaves of the plant were purchased and authenticated. Oil extraction was done using Hydro-distillation method. Clinical isolates of Candida from denture wearers was speciated using CHROMagar. Well Diffusion test was used to confirm the antifungal activity. Hydro-distillation & Maceration methods of extraction were compared. MIC/MFC was determined using CSLI guidelines. Infra-Red Spectroscopy was used to identify the active functional group.
resultsO.vulgare showed 30±3mm of zone of inhibition as against 19mm for fluconazole. The suitable extraction method was Hydro-distillation. MIC & MFC were found to be 0.024% and 0.097% respectively which was much lesser than for fluconazole (0.25%). The active functional group had chemically similar structure as Carvacrol, usually found in antifungal herbs.
conclusionwithin the limitations of the study, it was concluded that (a)O.vulgare is anticandidal for clinical isolates of oral Candida, (b) Hydro-distillation is an effective method as compared to Maceration (c) MIC & MFC are much lower than that of fluconazole (d) the major functional group was structurally similar to Carvacrol.
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