Evidence map›Paper›PMID 29961922›Full record

ArticleProgress in orthodontics2018

Association between polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted bisphenol A levels after orthodontic bracket bonding: a preliminary study.

Karla C Horta, Guido A Marañón-Vásquez, Mírian A N Matsumoto, Marília R Moreira, Fábio L Romano, Alberto Consolaro, Israel D de Souza, Tamires A V Brigante, Maria E C Queiroz, Paulo Nelson-Filho and 1 more

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Article in Progress in orthodontics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Karla C HortaDepartment of Pediatric Dentistry, Orthodontic Area, Ribeirão Preto Dental School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Guido A Marañón-VásquezDepartment of Pediatric Dentistry, Orthodontic Area, Ribeirão Preto Dental School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Mírian A N MatsumotoDepartment of Pediatric Dentistry, Orthodontic Area, Ribeirão Preto Dental School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Marília R MoreiraDepartment of Pediatric Dentistry, Ribeirão Preto Dental School, University of São Paulo, Av. Do Café s/n, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil.
Fábio L RomanoDepartment of Pediatric Dentistry, Orthodontic Area, Ribeirão Preto Dental School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Alberto ConsolaroDepartment of Stomatology, Bauru Dental School, University of São Paulo, Bauru, São Paulo, Brazil.
Israel D de SouzaDepartment of Chemistry, Ribeirão Preto School of Philosophy, Science and Literature, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Tamires A V BriganteDepartment of Chemistry, Ribeirão Preto School of Philosophy, Science and Literature, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Maria E C QueirozDepartment of Chemistry, Ribeirão Preto School of Philosophy, Science and Literature, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Paulo Nelson-FilhoDepartment of Pediatric Dentistry, Ribeirão Preto Dental School, University of São Paulo, Av. Do Café s/n, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil.
Erika C KüchlerDepartment of Pediatric Dentistry, Ribeirão Preto Dental School, University of São Paulo, Av. Do Café s/n, Monte Alegre, Ribeirão Preto, São Paulo, 14040-904, Brazil. erikacalvano@gmail.com.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/06866-5
6 · The paper itself

Abstract

backgroundBisphenol A (BPA) is released from orthodontic composites used for bracket bonding. Genetic variations could modify the metabolism of this chemical within the organism. Considering that free BPA binds to estrogen receptors causing harmful effects to health, the present in vivo study aimed to evaluate the association between genetic polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted BPA levels in orthodontic patients.

methodsQuantification of BPA levels in the urine of 16 patients was performed in a gas chromatograph mass spectrometer before (T0), at 24 h (T1), and 1 week (T2) after bracket bonding. DNA was extracted from saliva, and one genetic polymorphism in ESR1 (rs2234693) and two in ESR2 (rs4986938 and rs1256049) were analyzed by real-time PCR. Increases in BPA levels in the urine at T1 and T2 were grouped according to the genotype, and mean differences were compared by unpaired T test or Mann-Whitney test according to the normality of the data. The established alpha was 5%.

resultsBPA levels increased significantly at T1 and T2. There were no statistically significant differences in the increases in BPA levels according to the genotype for any genetic polymorphism (P > 0.05), at neither 24 h nor 1 week after bracket bonding.

conclusionsThe results suggested that there are no association between excreted BPA levels after bracket bonding and the evaluated genetic polymorphisms in ESR1 and ESR2. Further research should be performed in order to confirm these results.

Indexed as

Orthodontic BracketsPolymorphism, Single NucleotideAdolescentBenzhydryl CompoundsBisphenol A CompoundsChildEstrogen Receptor alphaEstrogen Receptor betaFemaleGas Chromatography-Mass SpectrometryGenotypeHumansMalePhenolsReal-Time Polymerase Chain ReactionResin CementsBenzhydryl Compoundsbisphenol ABisphenol A CompoundsESR1 protein, humanESR2 protein, humanEstrogen Receptor alphaEstrogen Receptor betaPhenolsResin CementsTransbond XTBisphenol AOrthodonticsPolymorphism

Identifiers

PMID29961922
PMCPMC6026583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.