Evidence map›Paper›PMID 29961859›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018

Acquisition of Multidrug-Resistant Human Immunodeficiency Virus Type 1 Infection in a Patient Taking Preexposure Prophylaxis.

Donn J Colby, Eugene Kroon, Carlo Sacdalan, Monica Gandhi, Robert M Grant, Praphan Phanuphak, Jintanat Ananworanich, Merlin L Robb, Nittaya Phanuphak

Abstract readCase Reports
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
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  5. Review
  6. Article
  7. Article
  8. Transmitted Drug Resistance Among Human Immunodeficiency Virus (HIV)-1 Diagnoses in the United States, 2014-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  9. Review
  10. Review
  11. Clinical Considerations in the Selection of Preexposure Prophylaxis for HIV Prevention in Canada.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
  12. Article
  13. Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Donn J ColbyThai Red Cross AIDS Research Centre, Bangkok, Thailand.
Eugene KroonThai Red Cross AIDS Research Centre, Bangkok, Thailand.
Carlo SacdalanThai Red Cross AIDS Research Centre, Bangkok, Thailand.
Monica GandhiUniversity of California, San Francisco.
Robert M GrantUniversity of California, San Francisco.
Praphan PhanuphakThai Red Cross AIDS Research Centre, Bangkok, Thailand.
Jintanat AnanworanichUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring.
Merlin L RobbUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring.
Nittaya PhanuphakThai Red Cross AIDS Research Centre, Bangkok, Thailand.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 1988 to 2026
$93.6M
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention TrialsR01AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA · 2012 to 2021
$5.6M
“Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.R37AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2023 to 2026
$3.2M
NIAID NIH HHS P30 AI027763NIAID NIH HHS R37 AI098472PEPFAR
6 · The paper itself

Abstract

We report a case indicating that acquisition of multidrug-resistant human immunodeficiency (HIV) virus type 1 during preexposure prophylaxis with combination tenofovir disoproxil fumarate and emtricitabine or evolution of resistance after HIV seroconversion remains a risk.

Indexed as

Drug Resistance, Multiple, ViralHIV SeropositivityPre-Exposure ProphylaxisAdultAnti-HIV AgentsEmtricitabineHIV-1HIV InfectionsHumansMaleMedication AdherenceRNA, ViralTenofovirThailandAnti-HIV AgentsEmtricitabineRNA, ViralTenofovir

Identifiers

PMID29961859
PMCPMC6117447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.