ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019
Assessment of Human-to-Human Transmissibility of Avian Influenza A(H7N9) Virus Across 5 Waves by Analyzing Clusters of Case Patients in Mainland China, 2013-2017.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Seroprevalence of H7N9 infection among humans: A systematic review and meta-analysis.Influenza and other respiratory viruses · 2020Pooled it
- Trial
- Trial
- Preparedness, prevention and control related to zoonotic avian influenza.EFSA journal. European Food Safety Authority · 2025Article
- Pandemic preparedness through vaccine development for avian influenza viruses.Human vaccines & immunotherapeutics · 2024Review
- The spatial-temporal distribution of hepatitis B virus infection in China,2006-2018.BMC infectious diseases · 2024Article
- Resilience as a measure of preparedness for pandemic influenza outbreaks.Health systems (Basingstoke, England) · 2024Article
- Bayesian phylodynamics reveals the transmission dynamics of avian influenza A(H7N9) virus at the human-live bird market interface in China.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Novel H7N9 influenza immunogen design enhances mobilization of seasonal influenza T cell memory in H3N2 pre-immune mice.Human vaccines & immunotherapeutics · 2022Article
- Spatio-temporal spread and evolution of influenza A (H7N9) viruses.Frontiers in microbiology · 2022Article
- The viral distribution and pathological characteristics of BALB/c mice infected with highly pathogenic Influenza H7N9 virus.Virology journal · 2021Article
- The distribution of hepatitis C virus infection in Shanghai, China: a time-spatial study.BMC infectious diseases · 2021Article
- H7N9 Influenza Virus in China.Cold Spring Harbor perspectives in medicine · 2021Review
- Reassortment with dominant chicken H9N2 influenza virus contributed to the fifth H7N9 virus human epidemic.Journal of virology · 2021Article
- Review
- Coronavirus and other airborne agents with pandemic potential.Current opinion in environmental science & health · 2020Review
- Human TRA2A determines influenza A virus host adaptation by regulating viral mRNA splicing.Science advances · 2020Article
- Live poultry market closure and avian influenza A (H7N9) infection in cities of China, 2013-2017: an ecological study.BMC infectious diseases · 2020Article
- Evolution and Adaptation of the Avian H7N9 Virus into the Human Host.Microorganisms · 2020Review
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
Background: The 2016-17 epidemic of human infections with avian influenza A(H7N9) virus was alarming, due to the surge in reported cases across a wide geographic area and the emergence of highly-pathogenic A(H7N9) viruses. Our study aimed to assess whether the human-to-human transmission risk of A(H7N9) virus has changed across the 5 waves since 2013. Methods: Data on human cases and clusters of A(H7N9) virus infection were collected from the World Health Organization, open access national and provincial reports, informal online sources, and published literature. We compared the epidemiological characteristics of sporadic and cluster cases, estimated the relative risk (RR) of infection in blood relatives and non-blood relatives, and estimated the bounds on the effective reproductive number (Re) across waves from 2013 through September 2017. Results: We identified 40 human clusters of A(H7N9) virus infection, with a median cluster size of 2 (range 2-3). The overall RR of infection in blood relatives versus non-blood relatives was 1.65 (95% confidence interval [CI]: 0.88, 3.09), and was not significantly different across waves (χ2 = 2.66, P = .617). The upper limit of Re for A(H7N9) virus was 0.12 (95% CI: 0.10, 0.14) and was not significantly different across waves (χ2 = 1.52, P = .822). Conclusions: The small cluster size and low Re suggest that human-to-human transmissibility of A(H7N9) virus has not changed over time and remains limited to date. Continuous assessment of A(H7N9) virus infections and human case clusters is of crucial importance for public health.
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