ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2018
Radiotherapy dose-volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: Results of a prospective registry.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients.The Cochrane database of systematic reviews · 2025Pooled it
- Risk prediction models for dysphagia after radiotherapy among patients with head and neck cancer: a systematic review and meta-analysis.Frontiers in oncology · 2025Pooled it
- Pooled it
- Hypoxia-Directed Treatment of Human Papillomavirus-Related Oropharyngeal Carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Trial
- Manual Therapy for Fibrosis-Related Late Effect Dysphagia in head and neck cancer survivors: the pilot MANTLE trial.BMJ open · 2021Trial
- Early MRI Blood Volume Changes in Constrictor Muscles Correlate With Postradiation Dysphagia.International journal of radiation oncology, biology, physics · 2021Trial
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- Deep learning NTCP model for late dysphagia after radiotherapy for head and neck cancer patients based on 3D dose, CT and segmentations.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025Article
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- Dysphagia at 1 Year is Associated With Mean Dose to the Inferior Section of the Brain Stem.International journal of radiation oncology, biology, physics · 2023Article
- Discriminant Ability of the Eating Assessment Tool-10 to Detect Swallowing Safety and Efficiency Impairments.The Laryngoscope · 2022Article
- Estimating the optimal linear combination of predictors using spherically constrained optimization.BMC bioinformatics · 2022Article
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- Dysphagia profiles after primary transoral robotic surgery or radiation for oropharyngeal cancer: A registry analysis.Head & neck · 2021Article
- Patient-Reported Outcomes-Guided Adaptive Radiation Therapy for Head and Neck Cancer.Frontiers in oncology · 2021Article
- The impact of tongue-deviating and tongue-depressing oral stents on long-term radiation-associated symptoms in oropharyngeal cancer survivors.Clinical and translational radiation oncology · 2020Article
- Prospective longitudinal patient-reported outcomes of swallowing following intensity modulated proton therapy for oropharyngeal cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2020Article
- A spatial neighborhood methodology for computing and analyzing lymph node carcinoma similarity in precision medicine.Journal of biomedical informatics · 2020Article
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Authors and funding
17 authors.
Funding
Abstract
purposeOur primary aim was to prospectively validate retrospective dose-response models of chronic radiation-associated dysphagia (RAD) after intensity modulated radiotherapy (IMRT) for oropharyngeal cancer (OPC). The secondary aim was to validate a grade ≥2 cut-point of the published videofluoroscopic dysphagia severity (Dynamic Imaging Grade for Swallowing Toxicity, DIGEST) as radiation dose-dependent. MATERIAL AND
methodsNinety-seven patients enrolled on an IRB-approved prospective registry protocol with stage I-IV OPC underwent pre- and 3-6 month post-RT videofluoroscopy. Dose-volume histograms (DVH) for swallowing regions of interest (ROI) were calculated. Dysphagia severity was graded per DIGEST criteria (dichotomized with grade ≥2 as moderate/severe RAD). Recursive partitioning analysis (RPA) and Bayesian Information Criteria (BIC) were used to identify dose-volume effects associated with moderate/severe RAD.
results31% developed moderate/severe RAD (i.e. DIGEST grade ≥2) at 3-6 months after RT. RPA found DVH-derived dosimetric parameters of geniohyoid/mylohyoid (GHM), superior pharyngeal constrictor (SPC), and supraglottic region were associated with DIGEST grade ≥2 RAD. V61 ≥ 18.57% of GHM demonstrated optimal model performance for prediction of DIGEST grade ≥2.
conclusionThe findings from this prospective longitudinal registry validate prior observations that dose to submental musculature predicts for increased burden of dysphagia after oropharyngeal IMRT. Findings also support dichotomization of DIGEST grade ≥2 as a dose-dependent split for use as an endpoint in trials or predictive dose-response analysis of videofluoroscopy results.
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