ArticleIndian heart journal
The association of plasma high-sensitivity C-reactive protein level with rheumatic heart disease: The possible role of inflammation.
Article in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- C-reactive protein-induced injury inMicrobiology spectrum · 2025Article
- Inflammatory Response Genes' Polymorphism Associated with Risk of Rheumatic Heart Disease.Journal of personalized medicine · 2024Article
- The Role of Inflammation and Oxidative Stress in Rheumatic Heart Disease.International journal of molecular sciences · 2022Review
- Identification of key immune-related genes and immune infiltration in atrial fibrillation with valvular heart disease based on bioinformatics analysis.Journal of thoracic disease · 2021Article
- Study of the relation between serum levels of long-acting penicillin and the inflammatory markers: C-reactive protein and interleukin-6 in patients with chronic rheumatic heart disease.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2021Article
- Role of inflammation in initiation and maintenance of atrial fibrillation in rheumatic mitral stenosis - An analytical cross-sectional study.Journal of arrhythmia · 2020Article
- Article
- Recurrence to persistence: Inflammatory markers in pediatric rheumatic heart disease.Annals of pediatric cardiologyArticle
- Detecting sub-clinical disease activity in patients with chronic rheumatic valvular heart disease.Indian heart journalArticle
- Inflammatory cytokine levels in rheumatic heart disease and their association with use of benzathine penicillin: A case-control pilot study.Indian heart journalArticle
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4 authors.
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Abstract
backgroundCurrently, it is not clear whether recurrent traumatic events lead to progression of rheumatic heart disease (RHD) after the incident of acute rheumatic fever or a persistent inflammatory state at the site of the valves. The aim of this study was to assess the possible association between plasma high sensitive C Reactive Protein (hs-CRP) level as an indicator of inflammation and RHD. MATERIALS &
methodsNinety patients with RHD and 90 healthy controls who had undergone complete echocardiographic examination were enrolled in this cross-sectional study. A score was given to each patient according to the severity of valvular involvement. Plasma hs-CRP level was checked for each patient by ELISA method twice with two-week interval, and the mean hs-CRP was calculated.
resultsThe mean plasma hs-CRP level in the case group was significantly higher compared to its level in the control group (2.59±4.82 and 0.55±0.43 in the case and control groups respectively, p<0.001). There was also a strong association between the level of plasma hs-CRP and the severity of rheumatic valvular involvement (p<0.001).
conclusionThe mean plasma hs-CRP level seems to have a significant association with RHD and its severity. Further studies are needed to determine the cause and effect relationship.
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