ArticleRedox report : communications in free radical research2018
Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells.
Article in Redox report : communications in free radical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
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- A combination of ethanol and arachidonic acid promotes steatosis and endoplasmic reticulum stress and impairs mitochondrial respiration in H9c2 cardiomyoblasts.Lipids in health and disease · 2025Article
- Cardiac redox imbalance upon disruption of selenocysteine decomposition in mice.American journal of physiology. Heart and circulatory physiology · 2025Article
- Dysregulated Redox Signaling and Its Impact on Inflammatory Pathways, Mitochondrial Dysfunction, Autophagy and Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2025Review
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- Nuclear respiratory factor-1 (NRF1) induction as a powerful strategy to deter mitochondrial dysfunction and senescence in mesenchymal stem cells.Aging cell · 2025Article
- Research progress on the pathogenesis of AKI complicated by ECMO.Clinical and experimental nephrology · 2025Review
- Mitochondrial membrane potential and oxidative stress interact to regulate Oma1-dependent processing of Opa1 and mitochondrial dynamics.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Differentiation activates mitochondrial OPA1 processing in myoblast cell lines.Mitochondrion · 2024Article
- Drp1: Focus on Diseases Triggered by the Mitochondrial Pathway.Cell biochemistry and biophysics · 2024Review
- Article
- OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases.Disease models & mechanisms · 2023Article
- [Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Review
- Antioxidative and Mitochondrial Protection in Retinal Pigment Epithelium: New Light Source in Action.International journal of molecular sciences · 2023Article
- Neuroprotective effect of phospholipase AFrontiers in pharmacology · 2022Article
- Discovering the Protective Effects of Resveratrol on Aflatoxin B1-Induced Toxicity: A Whole Transcriptomic Study in a Bovine Hepatocyte Cell Line.Antioxidants (Basel, Switzerland) · 2021Article
- MitoQ Is Able to Modulate Apoptosis and Inflammation.International journal of molecular sciences · 2021Article
- Mitochondrial OPA1 cleavage is reversibly activated by differentiation of H9c2 cardiomyoblasts.Mitochondrion · 2021Article
- Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review.Frontiers in cell and developmental biology · 2021Review
- PPARγ in Ischemia-Reperfusion Injury: Overview of the Biology and Therapy.Frontiers in pharmacology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo explore the impact of oxidative insults on mitochondrial dynamics. In mammalian cells, oxidative insults activate stress response pathways including inflammation, cytokine secretion, and apoptosis. Intriguingly, mitochondria are emerging as a sensitive network that may function as an early indicator of subsequent cellular stress responses. Mitochondria form a dynamic network, balancing fusion, mediated by optic atrophy-1 (OPA1), and fission events, mediated by dynamin-related protein-1 (DRP1), to maintain homeostasis.
methodsHere, we examine the impact of oxidative insults on mitochondrial dynamics in 143B osteosarcoma and H9c2 cardiomyoblast cell lines via confocal microscopy, flow cytometry, and protein-based analyses.
resultsWhen challenged with hydrogen peroxide (H DISCUSSION: Taken together, these findings indicate that oxidative insults damage OPA1-mediated mitochondrial dynamics in mammalian cells via activation of OMA1, consistent with an emerging role for mitochondrial dynamics as an early indicator of cellular stress signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.