Evidence map›Paper›PMID 29961309›Full record

ReviewThe Korean journal of internal medicine2018

Hepatitis C virus infection in chronic kidney disease: paradigm shift in management.

So Mi Kim, Il Han Song

Abstract readReview
In one paragraph

Review in The Korean journal of internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Renal Function in Chronic Hepatitis C Patients in Mongolia.Diagnostics (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. [Sustained virologic response in patients with hepatitis C and chronic kidney disease].Revista medica del Instituto Mexicano del Seguro Social · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

So Mi KimDivision of Nephrology, Department of Internal Medicine, Dankook University Hospital, Cheonan, Korea.
Il Han SongDivision of Hepatology, Department of Internal Medicine, Dankook University Hospital, Cheonan, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is associated with increased liver-related morbidity and mortality rates, accelerated progression to end-stage renal disease, and risk of cardiovascular events. CKD patients with HCV infection require antiviral therapy. Pegylated interferon (peg-IFN) plus ribavirin was the standard of care for HCV-infected CKD patients before the introduction of first-generation direct-acting antiviral (DAA) oral anti-HCV agents. Peg-IFN-based treatment has a low virologic response rate and poor compliance, resulting in a high dropout rate. Recently, several clinical trials of all-DAA combination regimens have reported excellent antiviral efficacy and few adverse drug reactions in HCV-infected patients with CKD. These positive results have revolutionized the treatment of chronic HCV infection in this population. In this review, we address the impact of chronic HCV infection in CKD patients, and discuss their management using next-generation DAAs.

Indexed as

Antiviral AgentsHepacivirusHepatitis C, ChronicRenal Insufficiency, ChronicDrug Therapy, CombinationHepatitis CHumansRibavirinAntiviral AgentsRibavirinDirect-acting agentsHepatitis C virusKidney transplantationRenal insufficiency, chronic

Identifiers

PMID29961309
PMCPMC6030406

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.