ArticleDevelopmental psychobiology2018
Are cortisol concentrations in human breast milk associated with infant crying?
Article in Developmental psychobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06197100 (Effectiveness of Supportive Care Training Given to Mothers of Babies With Infant Colic), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Supportive Care Training Given to Mothers of Babies With Infant Colic: Randomized Controlled Study
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- From Mind to Milk: The Influence of Psychological Factors on the Composition of Human Breast Milk.Nutrients · 2025Pooled it
- Crying in the first 12 months of life: A systematic review and meta-analysis of cross-country parent-reported data and modeling of the "cry curve".Child development · 2022Pooled it
- The effect of behavioral therapy based counseling with anxious mothers on their infants' colic: a randomized controlled clinical trial.BMC pediatrics · 2022Trial
- Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial.Scientific reports · 2021Trial
- Investigating the Impact of Maternal Stress on Milk Glucocorticoids: A Multimethod Approach.Psychophysiology · 2025Article
- Association of maternal psychological distress and milk cortisol with infant temperament and growth.Scientific reports · 2025Article
- Assessment of Heat Processing Effects on Cortisol Concentration in Dairy Milk Products.Food science of animal resources · 2024Article
- Is domestic violence during COVID-19 in lactating women related to infantile colic? An important question.BMC public health · 2024Article
- Association between maternal stress and premature milk cortisol, milk IgA, and infant health: a cohort study.Frontiers in nutrition · 2024Article
- Fucosylated Human Milk Oligosaccharides during the First 12 Postnatal Weeks Are Associated with Better Executive Functions in Toddlers.Nutrients · 2023Article
- Factors Influencing Cortisol Concentrations in Breastmilk and Its Associations with Breastmilk Composition and Infant Development in the First Six Months of Lactation.International journal of environmental research and public health · 2022Article
- Glucocorticoids in preterm human milk.Frontiers in nutrition · 2022Article
- DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring.Nutrients · 2021Article
- Do Breastfeeding History and Diet Quality Predict Inhibitory Control at Preschool Age?Nutrients · 2021Article
- Structure-Specific and Individual-Dependent Metabolization of Human Milk Oligosaccharides in Infants: A Longitudinal Birth Cohort Study.Journal of agricultural and food chemistry · 2021Article
- Tracking Infant Development With a Smartphone: A Practical Guide to the Experience Sampling Method.Frontiers in psychology · 2021Review
- Diurnal rhythmicity in breast-milk glucocorticoids, and infant behavior and sleep at age 3 months.Endocrine · 2020Article
- The association between breastmilk oligosaccharides and faecal microbiota in healthy breastfed infants at two, six, and twelve weeks of age.Scientific reports · 2020Article
- 'Optimising' breastfeeding: what can we learn from evolutionary, comparative and anthropological aspects of lactation?BMC medicine · 2020Article
- Human milk cortisol and immune factors over the first three postnatal months: Relations to maternal psychosocial distress.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present longitudinal study is the first to investigate the association between human breast milk cortisol and infant crying over the first three months of life. Higher concentrations of breast milk cortisol were expected to be differentially associated with fussing and crying in boys and girls. At 2, 6, and 12 weeks of infant age, mothers (N = 70) collected a morning sample of their milk and kept a 3-day diary to measure infant fussing and crying. Cortisol was extracted and quantified from milk samples. Results showed that breast milk cortisol concentrations increased from 2 weeks through 12 weeks of infant age. Milk cortisol was unrelated to the total duration, frequency, and bout length of infant fussing and crying for both boys and girls. Directions for future research aiming to extend our knowledge on the biology of milk cortisol in relation to infant behavior and development are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.