Evidence map›Paper›PMID 29961201›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2018

Hyperhomocysteinemia influenced malnutrition in Parkinson's disease patients.

Svetlana Tomic, Vlasta Pekic, Zeljka Popijac, Tomislav Pucic, Marta Petek Vinkovic, Tihana Gilman Kuric, Zvonimir Popovic

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Fractures in Parkinson's Disease: injury patterns, hospitalization, and therapeutic aspects.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Svetlana TomicClinical Department of Neurology, Osijek University Hospital Center, J. Huttlera 4, HR-31000, Osijek, Croatia. svetlana.tomic@vip.hr.ORCID http://orcid.org/0000-0002-1613-3831
Vlasta PekicClinical Department of Neurology, Osijek University Hospital Center, J. Huttlera 4, HR-31000, Osijek, Croatia.
Zeljka PopijacClinical Department of Neurology, Osijek University Hospital Center, J. Huttlera 4, HR-31000, Osijek, Croatia.
Tomislav PucicClinical Department of Neurology, Osijek University Hospital Center, J. Huttlera 4, HR-31000, Osijek, Croatia.
Marta Petek VinkovicClinical Department of Neurology, Osijek University Hospital Center, J. Huttlera 4, HR-31000, Osijek, Croatia.
Tihana Gilman KuricClinical Department of Neurology, Osijek University Hospital Center, J. Huttlera 4, HR-31000, Osijek, Croatia.
Zvonimir PopovicClinical Department of Neurology, Osijek University Hospital Center, J. Huttlera 4, HR-31000, Osijek, Croatia.
University of Osijek · HRKlinički bolnički centar Osijek · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionParkinson's disease (PD) is a neurodegenerative disease with many motor and non-motor symptoms. Hyperhomocysteinemia is reported in many PD patients. Homocysteine (Hcy) is reported to be a risk factor for some PD non-motor symptoms.

aimThe aim was to analyze Hcy level and its correlation with physical activity and motor and some non-motor symptoms (depression and cognition) in PD patients. PATIENTS AND

methodsPatients were surveyed for physical activity and demographic data. Blood samples were obtained for Hcy, vitamin B12, and folic acid determination. The Mini Nutritional Assessment (MNA), Unified Parkinson's Disease Rating Scale (UPDRS) parts III and IV, Hoehn and Yahr (H&Y) Scale, Beck Depression Inventory (BDI), and Mini Mental State Examination (MMSE) were used to assess nutritional status, disease stage, and motor and some non-motor symptoms (depression and cognition) of PD in study patients.

resultsWe analyzed 34 PD patients. Elevated Hcy level was found in 70.6% of these patients. Patients reporting regular exercise had lower Hcy level (p < 0.025). Hcy level yielded a statistically significant correlation with MNA score (rs = - 0.510; p < 0.003), UPDRS part III (rs = 0.372; p < 0.030), vitamin B12 (rs = - 0.519; p < 0.002), and folic acid (rs = - 0.502; p < 0.003) but not with cognition and depression. There were no statistically significant differences in Hcy level for disease stage either for dyskinesia or "off" periods.

conclusionPD patients are at a risk of hyperhomocysteinemia. Regular physical activity decreases Hcy level, whereas poor motor function increases it. There is correlation between Hcy level and malnutrition in PD patients.

Indexed as

AgedAged, 80 and overExerciseFemaleHumansHyperhomocysteinemiaMaleMalnutritionMental Status and Dementia TestsMiddle AgedParkinson DiseaseSeverity of Illness IndexStatistics, NonparametricHyperhomocysteinemiaMalnutritionParkinson’s diseasePhysical activity

Identifiers

PMID29961201
OpenAlexW2809707982

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.