ArticleBehavior genetics2018
Revisiting the Children-of-Twins Design: Improving Existing Models for the Exploration of Intergenerational Associations.
Article in Behavior genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A meta-analysis of genetic effects associated with neurodevelopmental disorders and co-occurring conditions.Nature human behaviour · 2023Pooled it
- Systematic Review and Meta-analysis of Genetically Informed Research: Associations Between Parent Anxiety and Offspring Internalizing Problems.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Pooled it
- Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature.Translational psychiatry · 2021Pooled it
- Triangulating evidence for genetic and environmental components of associations between parental behaviours and aggressive behaviour in children.Nature communications · 2026Article
- Parental body mass index and offspring childhood body size and eating behaviour: A structural equation modelling analysis in the Norwegian Mother, Father and Child Cohort Study.PLoS medicine · 2026Article
- The Power to Resolve Cultural Transmission and Sibling Interaction Using Polygenic Scores.Behavior genetics · 2026Article
- Parental income and psychiatric disorders from age 10 to 40: a genetically informative population study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Understanding indirect assortative mating and its intergenerational consequences for educational attainment.Nature communications · 2025Article
- Socioeconomic status and risk for child psychopathology: exploring gene-environment interaction in the presence of gene-environment correlation using extended families in the Norwegian Mother, Father and Child Birth Cohort Study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- The Challenges and Opportunities for Mental Health Twin Research in Nigeria.Behavior genetics · 2024Article
- The Colombo Twin and Singleton Study (COTASS): Piloting the Feasibility of Collecting Nutritional Data and Extension of the Sample to Include Children of Twins.Behavior genetics · 2024Article
- Mothers' symptoms of anxiety and depression and the development of child temperament: A genetically informative, longitudinal investigation.JCPP advances · 2023Article
- Children of parents with depression or anxiety: Long-term follow-up, causality and resilience.JCPP advances · 2023Article
- Assessing aetiological overlap between child and adult attention-deficit hyperactivity disorder symptoms in an extended family design.BJPsych open · 2023Article
- Genetic associations with parental investment from conception to wealth inheritance in six cohorts.Nature human behaviour · 2023Article
- Maximizing the value of twin studies in health and behaviour.Nature human behaviour · 2023Review
- Annual Research Review: Towards a deeper understanding of nature and nurture: combining family-based quasi-experimental methods with genomic data.Journal of child psychology and psychiatry, and allied disciplines · 2023Review
- Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study.Molecular psychiatry · 2023Article
- Intergenerational transmission of psychopathology: An examination of symptom severity and directionality.Development and psychopathology · 2022Article
- Parental criticism and adolescent internalising symptoms: using a Children-of-Twins design with power calculations to account for genetic influence.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Datasets comprising twins and their children can be a useful tool for understanding the nature of intergenerational associations between parent and offspring phenotypes. In the present article we explore structural equation models previously used to analyse Children-of-Twins data, highlighting some limitations and considerations. We then present new variants of these models, showing that extending the models to include multiple offspring per parent addresses several of the limitations discussed. Accompanying the updated models, we provide power calculations and demonstrate with application to simulated data. We then apply to intergenerational analyses of height and weight, using a sub-study of the Norwegian Mother and Child Cohort (MoBa); the Intergenerational Transmission of Risk (IToR) project, wherein all kinships in the MoBa data have been identified (a children-of-twins-and-siblings study). Finally, we consider how to interpret the findings of these models and discuss future directions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.