Evidence map›Paper›PMID 29961138›Full record

Trial reportClinical oral investigations2019

Effectiveness of adjunctive hyaluronic acid application in coronally advanced flap in Miller class I single gingival recession sites: a randomized controlled clinical trial.

Andrea Pilloni, Patrick R Schmidlin, Philipp Sahrmann, Anton Sculean, Mariana A Rojas

Erratum issued 4 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 4 registered trials, which are not on this map. Cited by 48 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 8 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04692558 phase4unknown statusnot on this mapstarted 2020, after this paper: background citation

Efficacy of Hyaluronic Acid on Connective Tissue Graft With Coronally Advanced Flap in the Treatment of Isolated Gingival Recession - A Randomized Controlled Clinical Trial.

TypeinterventionalSponsorKrishnadevaraya College of Dental Sciences & HospitalRan2020 to 2021Enrolled20ConditionsGingival RecessionArmsHYALURONIC ACID, coronally advanved flap with connective tissue harvesting
NCT06914518 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Polynucleotide and Hyaluronic Acid-based Gel as Adjunctive Therapy to Non- Surgical Treatment of Intraosseous Peri-implant Defect. A 6-month Randomized Clinical Trial

TypeinterventionalSponsorUniversitat Internacional de CatalunyaRan2025 to 2026Enrolled32ConditionsPeri-implantitisArmsviscoelastic gel containing a fixed combination of natural origin PN (10 mg/ml, 1%) and HA with molecular weight > 1500 kDa (10 mg/ml, 1%), Non-Surgical Intervention
NCT07529340 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Hyaluronic Acid Application in Coronally Advanced Flap Combined With a Subepithelial Connective Tissue Graft Versus Coronally Advanced Flap Combined With a Subepithelial Connective Tissue Graft Alone: A Clinical Trial

TypeinterventionalSponsorUniversidade do PortoRan2026 to 2027Enrolled34ConditionsGingival Recession, Mucogingival SurgeryArmsCoronally Advanced Flap with Connective Tissue Graft, Cross-linked Hyaluronic Acid Gel
NCT07771244 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Assessment of Injectable Hyaluronic Acid Combined With Polynucleotides With Coronally Advanced Flap and Connective Tissue Graft in Treatment of RT II Gingival Recession Defects for Covering Gingival Recession

TypeinterventionalSponsorCairo UniversityRan2026 to 2027Enrolled12ConditionsRT II Gingival RecessionArmsCoronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid/Polynucleotides
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 8 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  7. Hyaluronic Acid: A New Approach for the Treatment of Gingival Recession-A Systematic Review.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Andrea PilloniSection of Periodontology, Department of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Rome, Italy.
Patrick R SchmidlinClinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Philipp SahrmannClinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
Anton SculeanDepartment of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Mariana A RojasSection of Periodontology, Department of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Rome, Italy. rojasmarianaandrea@gmail.com.ORCID http://orcid.org/0000-0002-8712-0958
Sapienza University of Rome · ITUniversity of Zurich · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this randomized controlled clinical trial was to evaluate the possible advantages of adjunctive hyaluronic acid (HA) application in the coronally advanced flap (CAF) procedure in single Miller class I/recession type 1 (RT1) gingival recession treatment. MATERIAL AND

methodsThirty patients with one recession were enrolled; 15 were randomly assigned CAF + HA and 15 to CAF alone. The recession reduction (RecRed), clinical attachment level gain (CAL-gain), changes in probing pocket depth (PPD) and in the width of keratinized tissue (KT), complete root coverage (CRC), and mean root coverage (MRC) were calculated after 18 months. Post-operative morbidity (pain intensity, discomfort, and swelling) was recorded 7 days after treatment using visual analogue scale (VAS).

resultsAfter 18 months, RecRed was statistically significantly higher in the test group (2.7 mm [1.0]) than in the control group (1.9 mm [1.0]; p = 0.007). PPD were found to be slightly but statistically significantly increased in both groups. No statistically significant difference was found for KT gain between treatments. CRC was 80% for test and 33.3% for control sites (p < 0.05). A MRC of 93.8 ± 13.0% for test and 73.1 ± 20.8% for control sites was calculated (p < 0.05). The test group reported lower swelling and discomfort values 7-days post-surgery (p < 0.05). Statistically significant difference was not found for pain intensity.

conclusionsThe adjunctive use of HA was effective in obtaining CRC for single Miller class I/RT1 gingival recession sites. CLINICAL RELEVANCE: Adjunctive application of HA in the coronally advanced flap procedure may improve the reduction of the recessions and increase the probability of CRC in Miller class I recessions.

Indexed as

Gingival RecessionConnective TissueFollow-Up StudiesGingivaHumansHyaluronic AcidPeriodontal Attachment LossTooth RootTreatment OutcomeHyaluronic AcidClinical trial(s)Cosmetic periodontal plastic surgeryGingival recessionHyaluronic acidMucogingival surgery

Identifiers

PMID29961138
OpenAlexW2810105222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.