ArticleJournal of the American Heart Association2018
Long-Term Mortality of Older Patients With Acute Myocardial Infarction Treated in US Clinical Practice.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Unsolved Questions in the Revascularization of Older Myocardial Infarction Patients with Multivessel Disease.Reviews in cardiovascular medicine · 2022Pooled it
- Sex-specific impact of diabetes on all-cause mortality among adults with acute myocardial infarction: An updated systematic review and meta-analysis, 1988-2021.Frontiers in endocrinology · 2022Pooled it
- Cardiac Rehabilitation Using the Family-Centered Empowerment Model is Effective in Improving Long-term Mortality in Patients with Myocardial Infarction: A 10-year Follow-Up Randomized Clinical Trial.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Trial
- Diabetes-associated short-term mortality after first-onset acute myocardial infarction: age- and residence-specific patterns in an underserved region.BMC public health · 2026Article
- Comparative long-term prognosis of acute myocardial infarction and acute aortic dissection in a population-based registry.European heart journal open · 2026Article
- Survival After the First Myocardial Infarction in Older Women: A Prospective Cohort Analysis From the WHI.Journal of the American Heart Association · 2026Article
- Predicting Mortality and Costs After Emergency Department Visits by People With Dementia: Timing and Location Matter.Journal of the American Geriatrics Society · 2026Article
- Treating myocardial infarction combined with depression via regulating M1/TNF-α/TNFR1/NF-κB.Biochemistry and biophysics reports · 2026Article
- Use of the Hypoxia-Age-Shock Index at Triage to Predict Mortality in Geriatric STEMI Patients Undergoing Primary PCI.Medicina (Kaunas, Lithuania) · 2026Article
- Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium.Nature cardiovascular research · 2025Article
- Targeted delivery of engineered adipose-derived stem cell secretome to promote cardiac repair after myocardial infarction.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- Enhanced machine learning models for predicting three-year mortality in Non-STEMI patients aged 75 and above.BMC geriatrics · 2025Article
- Feasibility and efficacy of mobile app implementation among patients with acute myocardial infarction enrolled in coordinated cardiac rehabilitation program.Frontiers in digital health · 2025Article
- Analysis of Compliance with Proper Nutrition Principles in Patients with a History of Myocardial Infarction.Nutrients · 2024Article
- Analysis of the prognostic value of mitochondria-related genes in patients with acute myocardial infarction.BMC cardiovascular disorders · 2024Article
- Management of Acute Coronary Syndromes in Older People: Comprehensive Review and Multidisciplinary Practice-Based Recommendations.Journal of clinical medicine · 2024Review
- Chronological vs Biological Age in Interventional Cardiology: A Comprehensive Approach to Care for Older Adults: JACC Family Series.JACC. Cardiovascular interventions · 2024Review
- In need of age-appropriate cardiac models: Impact of cell age on extracellular matrix therapy outcomes.Aging cell · 2023Article
- Conservative versus Invasive Strategy in Elderly Patients with Non-ST-Elevation Myocardial Infarction: Insights from the International POPular Age Registry.Journal of clinical medicine · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundThere is limited information about the long-term survival of older patients after myocardial infarction (MI). METHODS AND
resultsCRUSADE (Can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines) was a registry of MI patients treated at 568 US hospitals from 2001 to 2006. We linked MI patients aged ≥65 years in CRUSADE to their Medicare data to ascertain long-term mortality (defined as 8 years post index event). Long-term unadjusted Kaplan-Meier mortality curves were examined among patients stratified by revascularization status. A landmark analysis conditioned on surviving the first year post-MI was conducted. We used multivariable Cox regression to compare mortality risks between ST-segment-elevation myocardial infarction and non-ST-segment-elevation myocardial infarction patients. Among 22 295 MI patients ≥ age 65 years (median age 77 years), we observed high rates of evidence-based medication use at discharge: aspirin 95%, β-blockers 94%, and statins 81%. Despite this, mortality rates were high: 24% at 1 year, 51% at 5 years, and 65% at 8 years. Eight-year mortality remained high among patients who underwent percutaneous coronary intervention (49%), coronary artery bypass graft (46%), and among patients who survived the first year post-MI (59%). Median survival was 4.8 years (25th, 75th percentiles 1.1, 8.5); among patients aged 65-74 years it was 8.2 years (3.3, 8.9) while for patients aged ≥75 years it was 3.1 years (0.6, 7.6). Eight-year mortality was lower among ST-segment-elevation myocardial infarction than non-ST-segment-elevation myocardial infarction patients (53% versus 67%); this difference was not significant after adjustment (hazard ratio 0.94, 95% confidence interval, 0.88-1.00).
conclusionsLong-term mortality remains high among patients with MI in routine clinical practice, even among revascularized patients and those who survived the first year.
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