Observational studyJournal of the American Heart Association2018
Extracellular Fluid Excess Is Significantly Associated With Coronary Artery Calcification in Patients With Chronic Kidney Disease.
Observational study in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02003781 (Individualized Prevention Strategy for High Risk Patients in Cardiovascular Disease), which is not on this map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Individualized Prevention Strategy for High Risk Patients in Cardiovascular Disease: Prospective Cohort Study (Cardiovascular and Metabolic Disease Etiology Research Center - HIgh Risk Cohort) CMERC-HI
Who cites it
32 citing papers in PubMed, 43 citations in OpenAlex.
- Effect of restrictive versus liberal fluid therapy for laparoscopic gastric surgery on postoperative complications: a randomized controlled trial.Journal of anesthesia · 2025Trial
- Trial
- The association between extracellular fluid volume and sympathetic nervous system activity in patients with chronic kidney disease.American journal of physiology. Renal physiology · 2026Article
- Association between body composition and its longitudinal changes with the progression of coronary artery calcification in hemodialysis patients.BMC nephrology · 2026Observational
- Ratio of extracellular water and body cell mass is associated with coronary artery calcification in peritoneal dialysis patients.Frontiers in medicine · 2026Article
- Association between Phase Angle and Subclinical Atherosclerosis in Asymptomatic Adults: A Large Scale Cross-Sectional and Longitudinal Study.Journal of atherosclerosis and thrombosis · 2026Article
- Elevated extracellular water to total body water ratio and low phase angle in relation to muscle function in middle-aged and older adults.Journal of the International Society of Sports Nutrition · 2025Article
- Once-Weekly Semaglutide Improves Body Composition in Spanish Obese Adults with Type 2 Diabetes: A 48-Week Prospective Real-Life Study.Journal of clinical medicine · 2025Article
- Changes in body composition and handgrip strength during dapagliflozin administration in patients with chronic kidney disease.Clinical kidney journal · 2025Article
- The ratio of extracellular water to total body water serves as a potential predictor of diabetic peripheral neuropathy in patients.Frontiers in endocrinology · 2025Article
- Water retention influences thigh skin temperature variation post-exercise: preliminary study of bioimpedance analysis and thermography data.Frontiers in sports and active living · 2025Article
- Left Atrial Volume versus Coronary Artery Calcium Score in Patients on Peritoneal Dialysis: An Observational Study.Journal of clinical medicine · 2024Article
- Extracellular fluid excess linked to reduced choroidal vascularity index in patients with chronic kidney disease.Scientific reports · 2024Article
- Analysis of the Associations of Measurements of Body Composition and Inflammatory Factors with Cardiovascular Disease and Its Comorbidities in a Community-Based Study.Biomedicines · 2024Article
- High sodium intake and fluid overhydration predict cardiac structural and functional impairments in chronic kidney disease.Frontiers in nutrition · 2024Article
- Whole-body water mass and kidney function: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Reduced body cell mass and functions in lower extremities are associated with mild cognitive impairment and Alzheimer's dementia.Scientific reports · 2023Article
- Genetic Variants Associated with Supernormal Coronary Arteries.Journal of atherosclerosis and thrombosis · 2023Article
- Assessment of Hydration, Nutritional Status and Arterial Stiffness in Hypertensive Chronic Kidney Disease Patients.Nutrients · 2023Article
- Nutritional Status of Coronary Artery Disease Patients-Preliminary Results.International journal of environmental research and public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtracellular fluid (ECF) excess is an independent predictor of cardiovascular morbidity in patients undergoing dialysis. This study aimed to investigate the relationship between ECF status, which is affected by renal function, and coronary artery calcification (CAC), which is a marker of cardiovascular disease, in patients with chronic kidney disease (CKD). METHODS AND
resultsA total of 1741 patients at all stages of pre-dialysis CKD from the prospective observational cohort of CMERC-HI (Cardiovascular and Metabolic Disease Etiology Research Center-High Risk) were analyzed for the association between ECF status and CAC. ECF status was defined as extracellular water-to-total body water ratio (ECW/TBW) measured using bioelectrical impedance analysis. ECF excess was defined as ECW/TBW ≥0.390 or ≥0.400 depending on its severity. To define CAC, Agatston coronary artery calcium scores were measured. A total coronary artery calcium score of ≥400 was defined as CAC. The CKD stages were defined according to estimated glomerular filtration rate calculated using the CKD Epidemiology Collaboration equation. ECW/TBW and the proportion of ECF excess increased with progressing CKD stages. Multivariable logistic regression analyses showed that ECW/TBW was independently associated with CAC (per 0.01 increase of ECW/TBW, odds ratio 1.168, 95% confidence interval, 1.079-1.264,
conclusionsECF status is independently associated with a high risk of CAC in patients with CKD. STUDY REGISTRATION: URL: https://www.clinicaltrials.gov/. Unique identifier: NCT02003781.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.