Evidence map›Paper›PMID 29960806›Full record

ArticleImmunobiology2018

Regulation of IL-10 and IL-17 mediated experimental autoimmune encephalomyelitis by S-nitrosoglutathione.

Inderjit Singh, Narender Nath, Nishant Saxena, Avtar K Singh, Je-Seong Won

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Inderjit SinghDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA; Research Service, Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC, USA. Electronic address: singhi@musc.edu.
Narender NathDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Nishant SaxenaDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Avtar K SinghDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA; Pathology and Laboratory Medicine Service, Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC, USA.
Je-Seong WonDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA. Electronic address: wonj@musc.edu.
Medical University of South Carolina · US

Funding

CYTOKINES IN GLIAL CELLS AND EAE BRAINR01NS037766 · NINDS · UNIVERSITY OF NEVADA RENO · PI SINGH, INDERJIT · 1998 to 2019
$5.9M
Immunomodulation and Neuroprotection in Multiple SclerosisI01BX002829 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI SINGH, INDERJIT · 2015 to 2025
–
BLRD VA I01 BX002829NINDS NIH HHS R01 NS037766
6 · The paper itself

Abstract

In this study, we investigated IL-10 and IL-17 specific immunomodulatory potential of S-nitrosoglutathione (GSNO), a physiological nitric oxide carrier molecule, in experimental autoimmune encephalomyelitis (EAE). In active EAE model, GSNO treatment attenuated EAE severity and splenic CD4

Indexed as

Adoptive TransferImmunomodulationAnimalsCD4-Positive T-LymphocytesEncephalomyelitis, Autoimmune, ExperimentalInterferon-gammaInterleukin-10Interleukin-17MiceMice, Inbred C57BLNitric Oxide DonorsS-NitrosoglutathioneTh17 CellsTh1 CellsIL10 protein, mouseIl17a protein, mouseInterferon-gammaInterleukin-10Interleukin-17Nitric Oxide DonorsS-NitrosoglutathioneAdoptive transferExperimental autoimmune encephalomyelitis (EAE)IL-10IL-17S-Nitrosoglutathione (GSNO)T(H)1T(H)17

Identifiers

PMID29960806
PMCPMC6093300
OpenAlexW2811194495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.