ArticleThe Journal of pediatrics2018
Presenting Signs and Symptoms do not Predict Aspiration Risk in Children.
Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Dietary management and feeding considerations of pediatric aerodigestive and upper gastrointestinal motility disorders.Journal of pediatric gastroenterology and nutrition · 2026Guideline
- Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2021Guideline
- Association Between Salivary Substance P and Aspiration on Videofluoroscopic Swallow Study in Infants and Toddlers.The Journal of pediatrics · 2026Article
- Incidence and factors associated with dysphagia in infants born very preterm or very low birth weight.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Enhancing the assessment of deglutition function in preterm infants with mechano-acoustic analysis and machine learning: a narrative review.Perspectives of the ASHA special interest groups · 2026Article
- Gatherings in Esophagology: Innovations and Future Directions in the Diagnosis and Management of Reflux Disease.Annals of the New York Academy of Sciences · 2026Article
- Prospective evaluation of clinical prediction rules for brief resolved unexplained event.Journal of pediatric gastroenterology and nutrition · 2026Article
- Thickened Liquids Improve Infant Swallow Function as Measured by Penetration-Aspiration Scale Score on Videofluoroscopic Swallow Study.Pediatric pulmonology · 2025Article
- A prospective study of diagnostic testing and hospital charges after brief resolved unexplained event.Journal of pediatric gastroenterology and nutrition · 2025Article
- Outcomes for infants with BRUE diagnosed with oropharyngeal dysphagia or gastroesophageal reflux disease: a multicenter study from the Pediatric Health Information System Database.European journal of pediatrics · 2025Article
- Brief Resolved Unexplained Events Symptoms Frequently Result in Inappropriate Gastrointestinal Diagnoses and Treatment.The Journal of pediatrics · 2024Article
- Breastfeeding in infants who aspirate may increase risk of pulmonary inflammation.Pediatric pulmonology · 2024Article
- Clinical feeding assessment: An effective screening test to predict aspiration in children in low resource settings.Journal of pediatric rehabilitation medicine · 2024Article
- Developing the Mansoura Early Feeding Skills Assessment Scale for Preterm Infants.Pediatric gastroenterology, hepatology & nutrition · 2023Article
- A Prospective Study of Parental Experience with Thickening Feeds for Children with Oropharyngeal Dysphagia and Gastroesophageal Reflux.The Journal of pediatrics · 2023Article
- Non-Pharmacological and Non-Surgical Feeding Interventions for Hospitalized Infants with Pediatric Feeding Disorder: A Scoping Review.Dysphagia · 2023Article
- A Prospective Study of Brief Resolved Unexplained Events: Risk Factors for Persistent Symptoms.Hospital pediatrics · 2022Article
- Videofluoroscopy compared with clinical feeding evaluation in children with suspected aspiration.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Pediatric Flexible Endoscopic Evaluation of Swallowing: Critical Analysis of Implementation and Future Perspectives.Dysphagia · 2022Article
- Summary for Clinicians: Clinical Practice Guidelines for Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease.Annals of the American Thoracic Society · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo determine if any presenting symptoms are associated with aspiration risk, and to evaluate the reliability of clinical feeding evaluation (CFE) in diagnosing aspiration compared with videofluoroscopic swallow study (VFSS). STUDY
designWe retrospectively reviewed records of children under 2 years of age who had evaluation for oropharyngeal dysphagia by CFE and VFSS at Boston Children's Hospital and compared presenting symptoms, symptom timing, and CFE and VFSS results. We investigated the relationship between symptom presence and aspiration using the Fisher exact test and stepwise logistic regression with adjustment for comorbidities. CFE and VFSS results were compared using the McNemar test. Intervals from CFE to VFSS were compared using the Student t test.
resultsA total of 412 subjects with mean (±SD) age 8.9 ± 6.9 months were evaluated. No symptom, including timing relative to meals, predicted aspiration on VFSS. This lack of association between symptoms and VFSS results persisted even in the adjusted multivariate model. The sensitivity of CFE for predicting aspiration by VFSS was 44%. Patients with a reassuring CFE waited 28.2 ± 8.5 days longer for confirmatory VFSS compared with those with a concerning CFE (P < .05).
conclusionsPresenting symptoms are varied in patients with aspiration and cannot be relied upon to determine which patients have aspiration on VFSS. The CFE does not have the sensitivity to consistently diagnose aspiration so a VFSS should be performed in persistently symptomatic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.