Evidence map›Paper›PMID 29960765›Full record

Observational studyThe Journal of pediatrics2018

Neurocognitive and Health Correlates of Overweight and Obesity among Ten-Year-Old Children Born Extremely Preterm.

Olivia Linthavong, T Michael O'Shea, Elizabeth Allred, Eliana Perrin, Melissa Bauserman, Robert M Joseph, Alan Leviton, Timothy C Heeren, Karl C K Kuban, Extremely Low Gestational Age Newborn (ELGAN) Research Study

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Olivia LinthavongDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, University of North Carolina, Chapel Hill, NC. Electronic address: olinthav@unch.unc.edu.
T Michael O'SheaDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, University of North Carolina, Chapel Hill, NC.
Elizabeth AllredDepartment of Neurology, Harvard University, Boston, MA.
Eliana PerrinDepartment of Pediatrics and Duke Center for Childhood Obesity Research, Duke University, Durham, NC.
Melissa BausermanDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, University of North Carolina, Chapel Hill, NC.
Robert M JosephDepartment of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA.
Alan LevitonDepartment of Neurology, Harvard University, Boston, MA.
Timothy C HeerenDepartment of Public Health, Boston University, Boston, MA.
Karl C K KubanDepartment of Child Neurology, Boston University, Boston, MA.
Extremely Low Gestational Age Newborn (ELGAN) Research Study

Funding

Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain DisordersU01NS040069 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI KUBAN, KARL · 2001 to 2014
$34.0M
The Role of the Placenta-Brain Axis in Children's NeurodevelopmentUH3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Rebecca Fry, Michael O'SHEA · 2018 to 2026
$21.9M
Environment, Epigenetics, Neurodevelopment & Health of Extremely Preterm ChildrenUG3OD023348 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA, O'SHEA, MICHAEL · 2016 to 2024
$7.4M
NIH HHS UG3 OD023348NIH HHS UH3 OD023348NINDS NIH HHS U01 NS040069
6 · The paper itself

Abstract

objectiveTo assess the relationship between overweight (body mass index [BMI] percentile ≥85 and <95) and obesity (BMI ≥95 percentile) and developmental and health outcomes at 10 years of age in a cohort of individuals born extremely preterm. STUDY

designThis was an observational cohort study of children born extremely preterm and then assessed at age 10 years for neurocognitive function and parent-reported behavior and health outcomes. Participants included 871 children aged 10 years. To describe the strength of association between overweight or obesity and outcomes, we used logistic regression models adjusting for confounders. Neurocognitive function, academic achievement, parent-reported health outcome surveys, and height and weight were measured.

resultsBMI category at 10 years of age was not associated with differences in intelligence, language, or academic achievement. Parents of children with obesity were more likely to report their child had asthma (OR 2.2; 95% CI 1.4-3.5), fair/poor general health (OR 3.2; 95% CI 1.4-7.5), and decreased physical function (OR 1.7; 95% CI 1.1-2.9) but less likely to have physician diagnosed attention-deficit/hyperactivity disorder (OR 0.5; 95% CI 0.3-0.97) or an individualized education plan (OR 0.6; 95% CI 0.4-0.99).

conclusionAmong children born extremely preterm, an elevated BMI, compared with normal or low BMI, is not associated with a difference in neurocognitive function. However, asthma, fair/poor general health, and decreased physical function were more prevalent among study participants with obesity, and attention-deficit/hyperactivity disorder and individualized education plan were less prevalent.

Indexed as

Health StatusInfant, Extremely PrematureQuality of LifeBody Mass IndexChildChild, PreschoolCognitionFemaleFollow-Up StudiesHumansInfantInfant, NewbornIntelligenceMaleOverweightPediatric Obesityasthmaextremely pretermneurocognitive outcomesobesityoverweight

Identifiers

PMID29960765
PMCPMC6109604

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.