ArticleJournal of pediatric surgery2018
The artificial placenta: Continued lung development during extracorporeal support in a preterm lamb model.
Article in Journal of pediatric surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Review
- Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes.Children (Basel, Switzerland) · 2025Review
- Human artificial placenta technology-trials: counselling and informed consent using healthcare professionals' and parental perspectives.Pediatric research · 2025Article
- Defining the threshold of birth: ethical introduction of artificial placenta and artificial womb technology in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Artificial womb technology - A more physiologic solution to treating extreme prematurity.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Article
- Reperfused human umbilical cords as anFrontiers in bioengineering and biotechnology · 2025Article
- Article
- Extracorporeal life support without systemic anticoagulation: a nitric oxide-based non-thrombogenic circuit for the artificial placenta in an ovine model.Pediatric research · 2024Article
- Ethical challenges in first-in-human trials of the artificial placenta and artificial womb: not all technologies are created equally, ethically.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- The artificial placenta and EXTEND technologies: one of these things is not like the other.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- An Artificial Placenta Experimental System in Sheep: Critical Issues for Successful Transition and Survival up to One Week.Biomedicines · 2023Article
- Development of an artificial placenta for support of premature infants: narrative review of the history, recent milestones, and future innovation.Translational pediatrics · 2021Review
- Advances in extracorporeal membrane oxygenator design for artificial placenta technology.Artificial organs · 2021Review
- Achieving sustained extrauterine life: Challenges of an artificial placenta in fetal pigs as a model of the preterm human fetus.Physiological reports · 2021Article
- Pediatric and neonatal extracorporeal life support: current state and continuing evolution.Pediatric surgery international · 2021Review
- A Pumpless Microfluidic Neonatal Lung Assist Device for Support of Preterm Neonates in Respiratory Distress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Splenic development and injury in premature lambs supported by the artificial placenta.Journal of pediatric surgery · 2019Article
- Gestational Age Influences the Early Microarchitectural Changes in Response to Mechanical Ventilation in the Preterm Lamb Lung.Frontiers in pediatrics · 2019Article
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Authors and funding
10 authors.
Funding
Abstract
purposeAn artificial placenta (AP) utilizing extracorporeal life support (ECLS) could avoid the harm of mechanical ventilation (MV) while allowing the lungs to develop.
methodsAP lambs (n = 5) were delivered at 118 days gestational age (GA; term = 145 days) and placed on venovenous ECLS (VV-ECLS) with jugular drainage and umbilical vein reinfusion. Lungs remained fluid-filled. After 10 days, lambs were ventilated. MV control lambs were delivered at 118 ("early MV"; n = 5) or 128 days ("late MV"; n = 5), and ventilated. Compliance and oxygenation index (OI) were calculated. After sacrifice, lungs were procured and H&E-stained slides scored for lung injury. Slides were also immunostained for PDGFR-α and α-actin; alveolar development was quantified by the area fraction of alveolar septal tips staining double-positive for both markers.
resultsCompliance of AP lambs was 2.79 ± 0.81 C
conclusionsLung development continues and lungs are protected from injury during AP support relative to mechanical ventilation. LEVEL OF EVIDENCE: n/a (basic/translational science).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.