ArticleThe Journal of the Acoustical Society of America2018
The influence of gas diffusion on bubble persistence in shock-scattering histotripsy.
Article in The Journal of the Acoustical Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Histotripsy-mediated reactive oxygen species generation in vitro.Ultrasonics · 2026Article
- Changes in bubble-cloud dissolution throughout the application of histotripsy pulses.Physical review applied · 2025Article
- The histotripsy spectrum: differences and similarities in techniques and instrumentation.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- Assessment of bubble activity generated by histotripsy combined with echogenic liposomes.Physics in medicine and biology · 2022Article
- Mechanisms of nuclei growth in ultrasound bubble nucleation.Ultrasonics sonochemistry · 2022Article
- Histotripsy Bubble Cloud Contrast With Chirp-Coded Excitation in Preclinical Models.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging.Physics in medicine and biology · 2021Article
- Factors Affecting Tissue Cavitation during Burst Wave Lithotripsy.Ultrasound in medicine & biology · 2021Article
- In vitro assessment of stiffness-dependent histotripsy bubble cloud activity in gel phantoms and blood clots.Physics in medicine and biology · 2019Article
- Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.Physics in medicine and biology · 2019Article
- For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy.Ultrasound in medicine & biology · 2019Review
- Coalescence of residual histotripsy cavitation nuclei using low-gain regions of the therapy beam during electronic focal steering.Physics in medicine and biology · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Bubble cloud persistence reduces the efficacy of mechanical liquefaction with shock-scattering histotripsy. In this study, the contribution of gas transfer to bubble longevity was investigated in silico by solving the equations for bubble oscillations and diffusion in parallel. The bubble gas content increased more than 5 orders of magnitude during the expansion phase, arresting the inertial collapse. The residual gas bubble required more than 15 ms for passive dissolution post excitation, consistent with experimental observation. These results demonstrate gas diffusion is an important factor in the persistence of histotripsy-induced cavitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.