Evidence map›Paper›PMID 29960275›Full record

ArticleThrombosis and haemostasis2018

Novel Immunoassay for Complement Activation by PF4/Heparin Complexes.

Sanjay Khandelwal, Alexandra M Johnson, Jian Liu, David Keire, Cynthia Sommers, Joann Ravi, Grace M Lee, John D Lambris, Edimara S Reis, Gowthami M Arepally

Abstract readComparative StudyLetter
In one paragraph

Article in Thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Methods to Examine Complement Activation by HIT Immune Complexes.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sanjay KhandelwalDivision of Hematology, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Alexandra M JohnsonDivision of Hematology, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Jian LiuDivision of Chemical Biology & Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States.
David KeireDivision of Pharmaceutical Analysis, CDER, Food and Drug Administration, St Louis, Missouri, United States.
Cynthia SommersDivision of Pharmaceutical Analysis, CDER, Food and Drug Administration, St Louis, Missouri, United States.
Joann RaviDivision of Hematology, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
Grace M LeeDivision of Hematology, Duke University Medical Center, Duke University, Durham, North Carolina, United States.
John D LambrisDepartment of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Edimara S ReisDepartment of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Gowthami M ArepallyDivision of Hematology, Duke University Medical Center, Duke University, Durham, North Carolina, United States.

Funding

Protein CoreP01HL110860 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI MCKENZIE, STEVEN E. · 2012 to 2016
$11.4M
In vitro synthesis of recombinant heparan sulfateR01HL094463 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIAN, PAWLINSKI, RAFAL L · 2009 to 2021
$5.2M
STRUCTURE-FUNCTION ANALYSIS OF DIFFERENT C3 SPECIESR01AI030040 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LAMBRIS, JOHN D · 1993 to 2016
$4.1M
Complement and CR2/CD21 in the Immune Pathogenesis of HITR01HL136512 · NHLBI · DUKE UNIVERSITY · PI AREPALLY, GOWTHAMI M · 2018 to 2021
$2.1M
PROBING HEPARIN STRUCTURAL ELEMENTS FOR HIGH RISK OF HEPARIN-INDUCED THROMBOCYTOPU19FD004994 · FDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIAN · 2013 to 2017
$1.3M
VIRAL RESPIRATORY PATHOGENS RESEARCH UNIT /VRPRU/-266030040-266030040N01AI030040 · NIAID · UNIVERSITY OF IOWA · PI APICELLA, MICHAEL A. · 2003 to 2006
–
FDA HHS U19 FD004994NHLBI NIH HHS P01 HL110860NHLBI NIH HHS R01 HL094463NHLBI NIH HHS R01 HL136512NIAID NIH HHS N01 AI030040NIAID NIH HHS R01 AI030040
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Complement ActivationAnimalsAntibodiesAnticoagulantsComplement C3HeparinHumansImmunoassayPlatelet Factor 4Predictive Value of TestsAntibodiesAnticoagulantsC3 protein, humanComplement C3HeparinPF4 protein, humanPlatelet Factor 4

Identifiers

PMID29960275
PMCPMC6288012

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.